A Natural Allele of a Transcription Factor in Rice Confers Broad-Spectrum Blast Resistance
A Natural Allele of a Transcription Factor in Rice Confers Broad-Spectrum Blast Resistance
复制标题
水稻转录因子的天然等位基因赋予广谱稻瘟病抗性
DOI：
10.1016/j.cell.2017.06.008
复制
发表时间：
2017-06-29
期刊：
影响因子：
64.5
通讯作者：
Chen, Xuewei
中科院分区：
文献类型：
--
作者：
Li, Weitao;Zhu, Ziwei;Chen, Xuewei
水稻养活了世界上一半的人口，而稻瘟病往往是一种破坏性疾病，导致重大作物损失。非小种特异性抗病性因其广谱性和持久性而比小种特异性抗病性更能有效地控制作物病害。通过全基因组关联研究，我们报告的C2 H2型转录因子在水稻中赋予非种族特异性抗稻瘟病的天然等位基因的鉴定。对3,000个测序水稻基因组的调查显示，该等位基因存在于10%的水稻中，这表明这种有利性状是通过育种选择的。该等位基因导致bsr-d1基因启动子中的单核苷酸变化，这通过抑制性MYB转录因子的结合导致该基因的表达减少，从而抑制H2 O2降解并增强抗病性。我们的发现强调了这种新的等位基因作为水稻持久抗性育种的策略。
Rice feeds half the world's population, and rice blast is often a destructive disease that results in significant crop loss. Non-race-specific resistance has been more effective in controlling crop diseases than race-specific resistance because of its broad spectrum and durability. Through a genome-wide association study, we report the identification of a natural allele of a C2H2-type transcription factor in rice that confers non-race-specific resistance to blast. A survey of 3,000 sequenced rice genomes reveals that this allele exists in 10% of rice, suggesting that this favorable trait has been selected through breeding. This allele causes a single nucleotide change in the promoter of the bsr-d1 gene, which results in reduced expression of the gene through the binding of the repressive MYB transcription factor and, consequently, an inhibition of H2O2 degradation and enhanced disease resistance. Our discovery highlights this novel allele as a strategy for breeding durable resistance in rice.