Batrachochytrium salamandrivorans.
Batrachochytrium salamandrivorans.
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Batrachochytrium salamdrivorans。
DOI：
10.1016/j.tim.2019.04.009
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发表时间：
2019
影响因子：
15.9
通讯作者：
Rhys A. Farrer
中科院分区：
文献类型：
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作者：
Rhys A. Farrer
最近发现的物种Batrachochytrium salamandivorans（Bsal）是蝾螈和蝾螈的真菌病原体，最近从亚洲传播到欧洲，对火蝾螈造成了毁灭性的破坏。这种疾病的特征是蝾螈皮肤上的多灶性浅表糜烂和深层溃疡，几种欧洲物种特别易感。虽然似乎未受影响，但无尾目（青蛙和蟾蜍）也可以作为Bsal携带者，人类贸易和种间/种内接触可能传播疾病。Bsal与20年前发现的通用两栖类病原体Batrachochytrium dendrobatium（Bd）密切相关。Bsal的基因组比Bd的基因组大（32 Mb），它编码100多个金属蛋白酶M36基因，与其溃疡病理学相关。对Bsal的群体遗传学以及Bd和Bsal之间的遗传差异的进一步研究应该揭示它们在宿主特异性、病理学和流行病学方面差异背后的机制。
The recently discovered species Batrachochytrium salamandivorans (Bsal) is a fungal pathogen of salamanders and newts that has recently spread from Asia into Europe, devastating the fire salamander. The disease is characterized by multifocal superficial erosions and deep ulcerations in the skin of salamanders, with several European species particularly susceptible. Although seemingly unaffected, the Anura (frogs and toads) can also act as Bsal carriers, with anthropogenic trade and inter/intraspecies contact likely spreading the disease. Bsal is closely related to the generalist amphibian pathogen Batrachochytrium dendrobatidis (Bd), which was discovered two decades prior. The genome of Bsal is larger (32 Mb) than that of Bd (23 Mb) and it encodes over 100 metalloprotease M36 genes, correlating with its ulcerative pathology. Further work on the population genetics of Bsal and genetic differences between Bd and Bsal should uncover the mechanisms behind their differences in host specificity, pathology, and epidemiology.