Soft strain-insensitive bioelectronics featuring brittle materials-猫眼课题宝

DOI：

10.1126/science.abn5142

发表时间：

2022-12

期刊：

Science

影响因子：

56.9

通讯作者：

中科院分区：

综合性期刊1区

文献类型：

作者：

Yichao Zhao;Bo Wang;Jiawei Tan;Hexing Yin;Ruyi Huang;Jialun Zhu;Shuyu Lin;Yan Zhou;David Jelinek;Zhengyang Sun;K. Youssef;L. Voisin;Abraham Horrillo;Kaiji Zhang;Benjamin M. Wu;H. Coller;Dan Lu;Q. Pei;S. Emaminejad

推进电子器件与组织相互作用需要同时满足电化学、电气和机械领域的材料约束。具有已建立的电化学功能的临床生物电极是刚性的，并且与组织机械不匹配。虽然导电材料具有类似组织的柔软性和可拉伸性，但当应用于电化学探针组织时，它们的性能会因应变和腐蚀而扭曲。我们设计了一种分层结构复合材料设计，该设计将应变诱导的破裂膜与应变隔离的平面外导电通路和平面内纳米线网络耦合，以消除应变对器件电化学性能的影响。因此，我们开发了一个图书馆的可拉伸，高导电性，应变不敏感的生物电极具有临床建立脆性界面材料（铱氧化物，金，铂，碳）。我们将这些生物电极与不同的电化学探测方法（安培法，伏安法和电位法）配对，并证明了多种生物标志物和体内神经调节的应变不敏感传感。描述在应变下保持柔软和导电大多数导电材料往往是坚硬和易碎的，而人体组织是柔软和顺应的。因此，制造足够柔顺但不显示性能损失或失真的导电生物材料是一个挑战。Zhao等人使用了一种三层设计，将应变诱导的破裂膜与应变隔离的导电通路相耦合（参见Rafeedi和Lipomi的观点）。当初始预应变达到100%时，顶部的脆性固体膜破裂以耗散应变能。然而，这种破裂允许一种平行的、互连的电荷传输，其中电荷载流子在层之间移动以绕过裂缝。-MSL使用脆性界面材料制作了一个柔软、可拉伸、应变不敏感的生物电子库。

Advancing electronics to interact with tissue necessitates meeting material constraints in electrochemical, electrical, and mechanical domains simultaneously. Clinical bioelectrodes with established electrochemical functionalities are rigid and mechanically mismatched with tissue. Whereas conductive materials with tissue-like softness and stretchability are demonstrated, when applied to electrochemically probe tissue, their performance is distorted by strain and corrosion. We devise a layered architectural composite design that couples strain-induced cracked films with a strain-isolated out-of-plane conductive pathway and in-plane nanowire networks to eliminate strain effects on device electrochemical performance. Accordingly, we developed a library of stretchable, highly conductive, and strain-insensitive bioelectrodes featuring clinically established brittle interfacial materials (iridium-oxide, gold, platinum, and carbon). We paired these bioelectrodes with different electrochemical probing methods (amperometry, voltammetry, and potentiometry) and demonstrated strain-insensitive sensing of multiple biomarkers and in vivo neuromodulation. Description Staying soft and conductive under strain Most electrically conductive materials tend to be stiff and brittle, whereas human tissue is soft and compliant. It is thus a challenge to make conductive biomaterials that are sufficiently compliant but do not show a loss or distortion in performance. Zhao et al. used a three-layer design to couple strain-induced cracked films with a strain-isolated conductive pathway (see the Perspective by Rafeedi and Lipomi). Upon an initial prestrain to 100%, the brittle solid film on top cracks to dissipate the strain energy. However, this cracking permits a type of parallel, interconnected charge transport in which the charge carriers move between the layers to circumvent the cracks. —MSL A library of soft, stretchable, strain-insensitive bioelectronics was made using brittle interfacial materials.

Soft strain-insensitive bioelectronics featuring brittle materials

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