Association of a SNP in the IAPP gene and hyperglycemia on β-cell dysfunction in type 2 diabetes: the Toon Genome Study.
Association of a SNP in the IAPP gene and hyperglycemia on β-cell dysfunction in type 2 diabetes: the Toon Genome Study.
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IAPP 基因中的 SNP 与 2 型糖尿病 β 细胞功能障碍的高血糖之间的关联：香椿基因组研究。
DOI：
10.1007/s13340-021-00523-4
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发表时间：
2021
期刊：
影响因子：
2.2
通讯作者：
and Osawa H.
中科院分区：
文献类型：
--
作者：
Kawamura R;Tabara Y;Takata Y;Maruyama K;Takakado M;Hadate T;Matsushita Y;Sano M;Makino H;Saito I;Kanatsuka A;and Osawa H.
在2型糖尿病中，胰岛的重要病理改变是淀粉样蛋白沉积。其主要成分是胰岛淀粉样多肽（IAPP）。本研究的目的是评估的可能性，在2型糖尿病的β-细胞功能障碍的IAPP基因型的影响是修改血浆glucose levels.MethodsParticipants从香椿基因组研究的变化进行了75克OGTT的葡萄糖耐量的诊断和胰岛素分泌的评价。我们研究了一个SNP，rs77397980，β-细胞功能的影响，通过分析之间的相互作用（统计）theIAPP基因型和AUC glucose.ResultsThe的C-等位基因携带者的比例基本上是相同的受试者之间的正常糖耐量，糖耐量受损和糖尿病。在糖尿病受试者中，沿着AUC葡萄糖的增加，空腹胰岛素在T/T纯合子中保持恒定，而在C等位基因携带者中似乎降低。稳态模型评估（HOMA）-IR出现前者增加，后者减少。在糖尿病受试者中，分层为AUC葡萄糖高于中位数的病例，C等位基因携带者的空腹胰岛素和HOMA-IR低于T/T纯合子。theIAPP基因型和AUC葡萄糖之间的相互作用表明HOMA-IR.ConclusionsThe的可能性，即关联betweenIAPP基因型和基础胰岛素水平的修改通过血浆葡萄糖的变化，导致在2型糖尿病基础胰岛素降低，不能被排除。
ObjectiveIn type 2 diabetes, the significant pathological change in pancreatic islets is amyloid deposits. Its major component is islet amyloid polypeptide (IAPP). The objective of this study was to evaluate the possibility that the effect of theIAPPgenotype on β-cell dysfunction in type 2 diabetes is modified by variations in plasma glucose levels.MethodsParticipants from the Toon Genome Study underwent a 75 g OGTT for the diagnosis of glucose tolerance and the evaluation of insulin secretion. We examined the effect of a SNP, rs77397980, on β-cell function by analyzing an interaction (statistics) between theIAPPgenotype and AUC glucose.ResultsThe ratio of the C-allele carriers was essentially the same among subjects with normal glucose tolerance, impaired glucose tolerance and diabetes. In subjects with diabetes, along with an increase in AUC glucose, fasting insulin remained constant in the T/T homozygotes and appeared to decrease in the C-allele carriers. A homeostasis model assessment (HOMA)-IR appeared to be increased in the former and decreased in the latter. In subjects with diabetes stratified into cases with higher AUC glucose than the median, fasting insulin and HOMA-IR were lower in the C-allele carriers than in the T/T homozygotes. An interaction between theIAPPgenotype and AUC glucose was indicated in the effect on HOMA-IR.ConclusionsThe possibility that the association betweenIAPPgenotype and basal insulin level is modified by variation in plasma glucose, resulting in a decreased basal insulin in type 2 diabetes, cannot be excluded.