Site-directed neovessel formation in vivo.
Site-directed neovessel formation in vivo.
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DOI：
10.1126/science.2457952
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发表时间：
1988-09
期刊：
影响因子：
56.9
通讯作者：
Jan Thompson;Anderson Kd;JM DiPietro;J. Zwiebel;M. Zametta;W. Anderson;T. Maciag
中科院分区：
文献类型：
--
作者：
Jan Thompson;Anderson Kd;JM DiPietro;J. Zwiebel;M. Zametta;W. Anderson;T. Maciag
血管生成是器官发生和伤口修复的重要组成部分，并且发生在肿瘤发生、动脉粥样硬化形成和其他疾病过程的病理过程中。因此，重要的是要了解控制新血管形成的生理机制，特别是允许在体内的现象的分子解剖的方法。肝素结合生长因子-1显示与I型和IV型胶原蛋白结合。当与明胶复合时，肝素结合生长因子-1可以在与体外有丝分裂原的生物活性一致的多肽浓度下诱导新血管形成。吸附策略诱导器官和组织特异性位点处和之间的快速血管形成，并允许通过分子方法回收位点特异性植入物用于检查和操作。
Angiogenesis is an important component of organogenesis and wound repair and occurs during the pathology of oncogenesis, atherogenesis, and other disease processes. Thus, it is important to understand the physiological mechanisms that control neovascularization, especially with methods that permit the molecular dissection of the phenomenon in vivo. Heparin-binding growth factor-1 was shown to bind to collagen type I and type IV. When complexed with gelatin, heparin-binding growth factor-1 can induce neovascularization at polypeptide concentrations that are consistent with the biological activity of the mitogen in vitro. The adsorption strategy induces rapid blood vessel formation at and between organ- and tissue-specific sites and permits recovery of the site-specific implant for examination and manipulation by molecular methods.