Gene expression changes associated with myocarditis and fibrosis in hearts of mice with chronic chagasic cardiomyopathy.
Gene expression changes associated with myocarditis and fibrosis in hearts of mice with chronic chagasic cardiomyopathy.
复制标题
DOI：
10.1086/653481
复制
发表时间：
2010-08-15
期刊：
影响因子：
--
通讯作者：
Spray DC
中科院分区：
文献类型：
--
作者：
Soares MB;de Lima RS;Rocha LL;Vasconcelos JF;Rogatto SR;dos Santos RR;Iacobas S;Goldenberg RC;Iacobas DA;Tanowitz HB;de Carvalho AC;Spray DC
慢性恰加斯心肌病是拉丁美洲国家心力衰竭的主要原因。大约 30% 的克氏锥虫感染者会出现这种严重的症状形式的疾病，其特征是强烈的炎症反应并伴有心脏纤维化。我们对患有这种疾病的小鼠模型的心脏进行了广泛的微阵列分析，并确定了约 12% 的采样基因的表达发生了显着变化。广泛的上调与免疫炎症反应（趋化因子、粘附分子、组织蛋白酶和 MHC 分子）和纤维化（细胞外基质成分、赖氨酰氧化酶和 Timp-1）相关。我们的结果表明该疾病发病机制中涉及的潜在相关因素可能为慢性恰加斯病提供新的治疗靶点。
Chronic chagasic cardiomyopathy is a leading cause of heart failure in Latin American countries. About 30% of Trypanosoma cruzi-infected individuals develop this severe symptomatic form of the disease, characterized by intense inflammatory response accompanied by fibrosis in the heart. We performed an extensive microarray analysis of hearts from a mouse model of this disease and determined significant alterations in expression of ∼12% of the sampled genes. Extensive upregulations were associated with immune-inflammatory responses (chemokines, adhesion molecules, cathepsins and MHC molecules) and fibrosis (extracellular matrix components, lysyl oxidase and Timp-1). Our results indicate potentially relevant factors involved in the pathogenesis of the disease that may provide new therapeutic targets in chronic Chagas' disease.
登录
查看更多内容
影响因子：
4.9
作者：
Garcia, S;Ramos, CO;Soares, MBP
通讯作者：
Soares, MBP
影响因子：
2.2
作者：
Laucella, S;Salcedo, R;Rottenberg, ME
通讯作者：
Rottenberg, ME
影响因子：
37.8
作者：
Machado, FS;Martins, GA;Silva, JS
通讯作者：
Silva, JS
影响因子：
4.8
作者：
LEDEBUR, HC;PARKS, TP
通讯作者：
PARKS, TP
影响因子：
168.9
作者：
Askari, AT;Unzek, S;Penn, MS
通讯作者：
Penn, MS