Stem cells and the impact of ROS signaling
Stem cells and the impact of ROS signaling
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DOI：
10.1242/dev.107086
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发表时间：
2014-11-01
期刊：
影响因子：
4.6
通讯作者：
Ghaffari, Saghi
中科院分区：
文献类型：
--
作者：
Bigarella, Carolina L.;Liang, Raymond;Ghaffari, Saghi
自我更新和分化之间的适当平衡对于干细胞在早期发育和整个生命过程中的组织稳态的功能至关重要。来自多能胚胎干细胞和成体干细胞研究的最新证据表明，这种平衡部分由活性氧（ROS）调节，活性氧与代谢同步，介导细胞的氧化还原状态。在这篇文章中，我们总结了ROS是什么，它们如何在细胞中产生，以及它们的下游分子靶点。然后，我们回顾了最近的研究结果，提供分子的见解如何ROS信号可以影响干细胞的稳态和谱系承诺，并讨论了这对重编程和干细胞衰老的影响。我们的结论是，ROS信号是一个新兴的多干细胞群体的关键调节。
An appropriate balance between self-renewal and differentiation is crucial for stem cell function during both early development and tissue homeostasis throughout life. Recent evidence from both pluripotent embryonic and adult stem cell studies suggests that this balance is partly regulated by reactive oxygen species (ROS), which, in synchrony with metabolism, mediate the cellular redox state. In this Primer, we summarize what ROS are and how they are generated in the cell, as well as their downstream molecular targets. We then review recent findings that provide molecular insights into how ROS signaling can influence stem cell homeostasis and lineage commitment, and discuss the implications of this for reprogramming and stem cell ageing. We conclude that ROS signaling is an emerging key regulator of multiple stem cell populations.