Potential biases in estimates of hepatitis C RNA clearance in newly acquired hepatitis C infection among a cohort of injecting drug users
Potential biases in estimates of hepatitis C RNA clearance in newly acquired hepatitis C infection among a cohort of injecting drug users
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DOI：
10.1017/s0950268806006388
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发表时间：
2007-01-01
影响因子：
4.2
通讯作者：
Dore, G. J.
中科院分区：
文献类型：
--
作者：
Amin, J.;Law, M. G.;Dore, G. J.
急性感染后丙型肝炎病毒(丙型肝炎病毒)清除的估计在14%到46%之间。这种广泛的范围可能是由于研究人群的特点和分析方法所致。这篇论文考察了不同的清除参数定义如何影响85名新感染丙型肝炎病毒的注射吸毒者的病毒清除估计。Kaplan-Meier对丙型肝炎病毒清除时间的估计是使用对合格队列、病毒清除、感染日期和清除日期的不同定义确定的。根据使用的定义组合，符合分析条件的受试者数量从27人到75人不等，清理率从14%到68%不等，达到25%的清理率从大约5个月到14个月不等。需要标准化的定义和方法，以便对新获得的丙型肝炎病毒感染自然史研究的清除率进行有效比较。
Estimates of hepatitis C virus (HCV) clearance following acute infection range from 14 to 46%. This wide range is likely to be due to the characteristics of the populations studied and analysis methods. This paper examines how differing definitions of clearance parameters affect estimates of viral clearance in a cohort of 85 injecting drug users with newly acquired HCV infection. Kaplan-Meier estimates of time to HCV clearance were determined using varying definitions of eligible cohort, viral clearance, date of infection and date of clearance. Based on which combinations of definitions were used, the number of subjects eligible for analysis ranged from 27 to 75, clearance rate ranged from 14 to 68% and time to achieving 25% clearance ranged from approximately 5 months to 14 months. Standardized definitions and methodologies are required to enable valid comparisons of rates of clearance across newly acquired HCV infection natural history studies.