The effect of lamivudine on the replication of hepatitis B virus in HIV-infected patients depends on the host immune status (CD4 cell count)

The effect of lamivudine on the replication of hepatitis B virus in HIV-infected patients depends on the host immune status (CD4 cell count)
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DOI:
10.1097/00002030-200307040-00023
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发表时间:
2003-07-04
期刊:
影响因子:
3.8
通讯作者:
Hoepelman, AIM
Hoepelman, AIM
中科院分区:
医学2区
文献类型:
--
作者:
Haverkamp, M;Smit, M;Hoepelman, AIM

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我们回顾性分析了拉米夫定对HIV合并感染患者的B型肝炎病毒(HBV)的影响。在这个小型研究中,我们记录了拉米夫定治疗对HBV复制的CD4细胞依赖性应答。在这方面,B型肝炎可被认为是机会性感染。我们的发现可能具有重要的临床意义,需要进行大规模的前瞻性研究来进一步研究。
We retrospectively analysed the effect of lamivudine on hepatitis B virus (HBV) in HIV-coinfected patients. In this small study we document a CD4 cell-dependent response on HBV replication with lamivudine therapy. In this respect, hepatitis B may be considered an opportunistic infection. Our finding may have important clinical consequences, and large prospective studies are necessary to investigate this further.