Manipulation of inhibin during the luteal-follicular phase transition of the primate menstrual cycle fails to affect FSH secretion.
Manipulation of inhibin during the luteal-follicular phase transition of the primate menstrual cycle fails to affect FSH secretion.
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在灵长类动物月经周期的黄体-卵泡相变过程中控制抑制素不会影响 FSH 的分泌。
DOI：
10.1677/joe.0.1420181
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发表时间：
1994
期刊：
影响因子：
--
通讯作者：
C. Tsonis
中科院分区：
文献类型：
--
作者：
H. Fraser;C. Tsonis
灵长类动物月经周期期间血液中抑制素浓度的模式表明，抑制素在黄体期 FSH 分泌的负反馈控制中发挥内分泌作用。相反，黄体后期抑制素的下降可能在黄体-卵泡相变期间血清 FSH 的升高中发挥作用。通过确定抑制素的操作对短尾猴 FSH 分泌的影响来检验这一假设。在黄体中期，推定的抑制素反馈被静脉注射抑制。对 4 只猕猴施用 20 ml 抗人重组抑制素绵羊抗血清。在治疗后的最初 24 小时内，FSH 分泌未受影响，并且在随后的黄体-卵泡期转变期间发生的 FSH 上升时间正常。为了确定在卵泡早期观察到的血清 FSH 浓度升高是否可以通过施用抑制素来降低，对 5 只周期性猕猴进行了 200 微克重组人抑制素静脉注射。血清 FSH 浓度未改变。这些结果表明，抑制素在黄体-卵泡相变过程中调节 FSH 分泌方面并不起主要作用。
The pattern of inhibin concentrations in blood during the menstrual cycle in primates has suggested an endocrine role of inhibin in the negative feedback control of FSH secretion during the luteal phase. Conversely, the fall in inhibin during the late luteal phase may play a role in the rise in serum FSH during the luteal-follicular phase transition. This hypothesis was examined by determining the effects of manipulation of inhibin on FSH secretion in stumptailed macaques. During the mid-luteal phase the putative inhibin feedback was inhibited by i.v. administration of 20 ml of ovine antiserum to human recombinant inhibin in 4 macaques. FSH secretion was unaffected during the initial 24 h period post-treatment and the timing of the rise in FSH which occurred during the subsequent luteal-follicular phase transition was normal. To determine whether the elevated serum concentrations of FSH observed during the early follicular phase could be reduced by administration of inhibin, 5 cyclic macaques were treated with 200 micrograms of recombinant human inhibin i.v. Serum FSH concentrations were unaltered. These results suggest that inhibin does not play a major role in modulating FSH secretion during the luteal-follicular phase transition.