Selenium status in patients receiving home parenteral nutrition.
Selenium status in patients receiving home parenteral nutrition.
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接受家庭肠外营养的患者的硒状况。
DOI：
10.1177/0148607184008003258
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发表时间：
1984
期刊：
影响因子：
--
通讯作者：
J. Petz
中科院分区：
文献类型：
--
作者：
C. Fleming;J. McCall;J. O'brien;R. Forsman;D. Ilstrup;J. Petz
对需要家庭肠外营养（HPN）的肠衰竭患者的硒（Se）状态进行了评价。92%的患者（11/12）在开始HPN前血清硒值较低，平均值为42 ng/ml，显著低于未接受HPN的克罗恩病对照组（76 ng/ml）和健康对照组（88 ng/ml）的平均值。85%的患者（26例中的22例）在研究时已经接受HPN 2至109个月，血清硒水平较低（平均38.4 ng/ml）。平均24小时尿硒值为3.7微克的HPN患者谁没有克罗恩病，10.9微克的HPN患者克罗恩病，和17.9微克的健康对照。在克罗恩病患者HPN，血清硒和全血谷胱甘肽过氧化物酶，硒蛋白的活性之间存在显着的直接相关性;和显着的负相关性，发现血清硒和月HPN。这项研究证实，硒缺乏症是非常常见的患者开始之前和期间HPN。这些数据和最近的报告与HPN患者缺硒相关的心肌病增加了适当的硒补充和维护的重要性。
Selenium (Se) status was evaluated in patients with intestinal failure requiring home parenteral nutrition (HPN). Ninety-two percent of patients (11 of 12) studied just prior to starting HPN had low serum Se values, and the mean value was 42 ng/ml, significantly less than mean values in disease controls with Crohn's disease not on HPN (76 ng/ml) and healthy controls (88 ng/ml). Eighty-five percent of patients (22 of 26) already on HPN for 2 to 109 months when studied had low serum Se levels (mean 38.4 ng/ml). The mean 24-hr urinary Se values were 3.7 micrograms in patients on HPN who did not have Crohn's disease, 10.9 micrograms in HPN patients with Crohn's, and 17.9 micrograms in healthy controls. In patients with Crohn's disease on HPN, a significant direct correlation existed between serum Se and the activity of whole blood glutathione peroxidase, a selenoprotein ; and a significant inverse correlation was found between serum Se and months of HPN. This study confirms that Se deficiency is very common in patients before starting and during HPN. These data and recent reports of cardiomyopathies associated with Se deficiencies in patients on HPN increase the importance of proper Se replacement and maintenance.
健康成人的硒代谢：使用稳定同位素 74SeO3(2-) 进行定量分析。
DOI：
10.1093/ajcn/35.4.647
发表时间：
1982
期刊：
The American journal of clinical nutrition
影响因子：
--
作者：
Janghorbani,M;Christensen,MJ;Nahapetian,A;Young,VR
通讯作者：
Young,VR