Clinical applications of magnetic drug targeting
Clinical applications of magnetic drug targeting
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DOI：
10.1006/jsre.2000.6030
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发表时间：
2001-02-01
影响因子：
2.2
通讯作者：
Bergemann, C
中科院分区：
文献类型：
--
作者：
Lübbe, AS;Alexiou, C;Bergemann, C
癌症患者通常表现为局部疾病。然而，手术根除或放射治疗并不总是可能或有意义的。药物靶向治疗是局部或区域抗肿瘤治疗的一种方式。磁控药物靶向是药物靶向的各种可能性之一。该技术基于将已建立的抗癌药物与铁流体结合，铁流体通过磁场将药物集中在感兴趣的区域（肿瘤部位）。然后，药物从铁磁流体中解吸并展开其作用机制。本文向读者概述了铁磁流体（磁性液体）与磁场结合的当前应用，因为它们与医学应用的最新进展，特别是抗癌治疗有关。(C)北京大学出版社.
Cancer patients often present with localized disease. Yet, surgical eradication or radiation treatment is not always possible or meaningful. Site-directed drug targeting is one way of local or regional antitumor treatment. Magnetically controlled drug targeting is one of the various possibilities of drug targeting. This technology is based on binding established anticancer drugs with ferrofiuids that concentrate the drug in the area of interest (tumor site) by means of magnetic fields. Then, the drug desorbs from the ferrofluid and enfolds its mechanism of action. This paper gives the reader an overview of current applications of ferrofluids (magnetic liquids) in conjunction with magnetic fields as they relate to the latest advances in medical applications and in particular to anticancer treatment. (C) 2000 Academic Press.