Effect of different chlorhexidine varnish regimens on mutans streptococci levels in interdental plaque and saliva.
Effect of different chlorhexidine varnish regimens on mutans streptococci levels in interdental plaque and saliva.
复制标题
不同洗必泰清漆方案对牙间菌斑和唾液中变形链球菌水平的影响。
DOI：
10.1159/000262397
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发表时间：
1997
期刊：
影响因子：
4.2
通讯作者：
L. Petersson
中科院分区：
文献类型：
--
作者：
S. Twetman;L. Petersson
本研究的目的是评估和比较的影响，密集和每月的抗菌清漆应用模式的变形链球菌（MS）的水平在牙间菌斑和整个唾液。通过筛选程序选择88名唾液MS评分较高的健康学龄儿童（11-13岁），并随机分为两组，采用改良椅旁技术在第一恒磨牙的所有近中牙间位点进行MS计数，共发现161个中度或高度定植水平的位点。受试者接受含1%洗必泰-百里酚的涂膜（Cervitec）治疗，在2周内以强化模式（IM）应用3次，或在3个月内以每月一次模式（MM）应用。在用牙线清洁牙间并风干后，用迷你球抛光器施加清漆。分别于术后1个月、3个月和6个月采集牙间区唾液和牙菌斑样本。与基线相比，两组在1个月后均显示出统计学显著（p > 0.05）的齿间MS减少。与MM相比，IM后MS生长消失的频率更高。3个月后，IM组与基线相比仍有显著降低，但MM组没有。6个月后，两组均未发现减少。除了IM组在1个月后略有下降外，唾液中的MS水平在随访采样时基本未受影响。总之，结果表明，洗必泰-百里酚清漆应用的密集模式比每月应用的模式对牙间MS更有效。细菌生长应监测在一个特定的网站的方式，因为牙间减少没有充分反映在整个唾液样本。
The aim of the present study was to evaluate and compare the effects of an intensive and a monthly mode of antibacterial varnish application on the levels of mutans streptococci (MS) in interdental plaque and whole saliva. Eighty-eight healthy schoolchildren (11-13 years) with high scores of salivary MS were selected by a screening procedure and randomised into two groups, MS were enumerated at all mesial interdental sites of the first permanent molars with the aid of a modified chair-side technique, disclosing a total of 161 sites with moderate or high colonisation levels. The subjects were treated with a 1% chlorhexidine-thymol-containing varnish (Cervitec) either in an intensive mode (IM) with 3 applications within a 2-week period or in a monthly mode (MM) during a 3-month period. The varnish was applied with a miniball burnisher after the teeth had been cleaned interdentally with dental floss and dried with air. Follow-up samples of saliva and plaque from the interdental areas were collected after 1, 3 and 6 months. Both groups exhibited a statistically significant (p > 0.05) reduction of interdental MS after 1 month when compared with baseline. An eliminated MS growth appeared more frequently following the IM compared with the MM. After 3 months, a significant reduction compared with baseline was still found in the IM group but not in the MM group. No reduction was found in either group after 6 months. MS levels in saliva were mainly unaffected at the follow-up samplings, with the exception of a slight reduction in the IM group after 1 month. In conclusion, the results suggest that an intensive mode of chlorhexidine-thymol varnish application is more effective against interdental MS than the monthly mode of application. Bacterial growth should be monitored in a site-specific way, since interdental reductions were not adequately reflected in whole saliva samples.