Signaling and stress: The redox landscape in NOS2 biology.
Signaling and stress: The redox landscape in NOS2 biology.
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DOI：
10.1016/j.freeradbiomed.2015.06.002
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发表时间：
2015-10
影响因子：
7.4
通讯作者：
Miranda KM
中科院分区：
文献类型：
--
作者：
Thomas DD;Heinecke JL;Ridnour LA;Cheng RY;Kesarwala AH;Switzer CH;McVicar DW;Roberts DD;Glynn S;Fukuto JM;Wink DA;Miranda KM
一氧化氮（NO）具有高度多样化的生物学功能，从生理信号传导和维持稳态到充当免疫系统中的效应分子。NO和衍生物活性氮物种（RNS）的许多二分法的影响，可以解释通过调用精确的相互作用与不同的目标作为一个结果的浓度和时间的限制。NO的内源性浓度跨越五个数量级，与免疫反应期间持续产生低微摩尔水平的NO相比，接近高皮摩尔范围的水平通常以短时间爆发的方式发生。本文提供了一个概述的氧化还原景观，因为它涉及到不断增加的NO浓度，这逐渐支配生理信号，亚硝化信号和亚硝化应激相关的信号。NO的生理信号主要发生在与血红素蛋白可溶性鸟苷酸环化酶相互作用后。随着NO浓度的升高，与非血红素铁络合物的相互作用以及硫醇的间接修饰可以刺激额外的信号传导过程。在最高水平的NO下，产生更广泛的RNS，随后与更多样化的靶标相互作用，可导致化学应激。然而，即使在这样的条件下，也有证据表明，与压力相关的信号传导机制被触发，以保护细胞甚至解决压力。因此，这篇评论还涉及基本的反应和动力学，启动信号通过NO依赖的途径，包括化学RNS及其分子靶点。
Nitric oxide (NO) has a highly diverse range of biological functions from physiological signaling and maintenance of homeostasis to serving as an effector molecule in the immune system. Many of the dichotomous effects of NO and derivative reactive nitrogen species (RNS) can be explained by invoking precise interactions with different targets as a result of concentration and temporal constraints. Endogenous concentrations of NO span five orders of magnitude, with levels near the high picomolar range typically occurring in short bursts as compared to sustained production of low micromolar levels of NO during immune response. This article provides an overview of the redox landscape as it relates to increasing NO concentrations, which incrementally govern physiological signaling, nitrosative signaling and nitrosative stress-related signaling. Physiological signaling by NO primarily occurs upon interaction with the heme protein soluble guanylyl cyclase. As NO concentrations rise, interactions with nonheme iron complexes as well as indirect modification of thiols can stimulate additional signaling processes. At the highest levels of NO, production of a broader range of RNS, which subsequently interact with more diverse targets, can lead to chemical stress. However, even under such conditions, there is evidence that stress-related signaling mechanisms are triggered to protect cells or even resolve the stress. This review therefore also addresses the fundamental reactions and kinetics that initiate signaling through NO-dependent pathways, including the chemistry of RNS and their molecular targets.
连续静脉输注白细胞介素2期间的血浆硝酸盐和亚硝酸盐的变化。
影响因子：
8.8
作者：
Citterio, G;Pellegatta, F;DiLucca, G;Fragasso, G;Scaglietti, U;Pini, D;Fortis, C;Tresoldi, M;Rugarli, C
通讯作者：
Rugarli, C