Microalbuminuria Is Common in Japanese Type 2 Diabetic Patients
Microalbuminuria Is Common in Japanese Type 2 Diabetic Patients
复制标题
微量白蛋白尿在日本 2 型糖尿病患者中很常见
作者：
H. Yokoyama;K. Kawai;M. Kobayashi
先前的研究报告称，2 型糖尿病患者微量白蛋白尿的患病率存在显着差异，范围为 7% 至 47% (1-13)。这种差异可能源于易感性的种族/遗传差异 (3-11) 以及调查患病率的方法问题，例如小规模人群 (3,12,13)；基于单一临床的研究 (8,12)；使用试纸法代替定量测定（4,5）；或仅对尿白蛋白排泄 (UAE) 进行一次测量 (3-13)，而多年来一直建议进行多次测量 (14)。为了调查 2 型糖尿病患者微量白蛋白尿的患病率，我们进行了这项研究，目的是调查特定种族（即日本人）的患者。该研究人口规模大、全国性多中心设计、临床变量和阿联酋多次测量的数据可用性比例很高。
作为一个工作研究组，开展了一项横断面研究，其中包括来自日本不同地区的 29 家医疗诊所（即全科医生）或综合/大学附属医院，使用相同的软件合并患者记录。该小组被称为日本糖尿病临床数据管理研究小组 (15)，由自愿致力于日常标准临床工作进行科学分析的医生组成。该研究进行...
Previous studies have reported a marked variation in the prevalence of microalbuminuria in type 2 diabetic patients ranging from 7 to 47% (1–13). The variation could arise from ethnic/genetic differences in susceptibility (3–11) and from methodological issues for investigating the prevalence, such as small-sized populations (3,12,13); single clinic–based studies (8,12); use of the dipstick method instead of quantitative determinations (4,5); or only a single measurement of urinary albumin excretion (UAE) (3–13), whereas multiple measurements have been recommended for years (14). In terms of investigating the prevalence of microalbuminuria in type 2 diabetic patients, we performed this study with the aim of investigating patients with a specific ethnicity (i.e., Japanese). The study had a large-sized population, a nationwide multicenter-based design, and a high proportion of data availability for clinical variables and for multiple measurements of UAE.
A cross-sectional study was conducted that included 29 medical clinics (i.e., general practitioners) or general/university-affiliated hospitals from different areas in Japan, using the same software to incorporate patient records, as a working study group. Known as the Japan Diabetes Clinical Data Management Study Group (15), this group consists of medical doctors who volunteered to dedicate daily standard clinical work to scientific analysis. The study was performed …