Association of Degree of European Genetic Ancestry With Serum Vitamin D Levels in African Americans
Association of Degree of European Genetic Ancestry With Serum Vitamin D Levels in African Americans
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DOI：
10.1093/aje/kwy015
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发表时间：
2018-07-01
影响因子：
5
通讯作者：
Palmer, Julie R.
中科院分区：
文献类型：
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作者：
Haddad, Stephen A.;Ruiz-Narvaez, Edward A.;Palmer, Julie R.
非裔美国人的维生素D循环水平通常低于美国白人，在少数非裔美国人中进行的1项先前分析表明，在该人群中，维生素D水平可能与遗传混合的程度有关。我们评估了来自黑人妇女健康研究的2，183名非洲裔美国妇女的欧洲血统百分比与血清维生素D水平之间的关联（2013-2015年评估），这些妇女的DNA已被基因分型为祖先信息标记物。使用ADMIXMAP软件估计每个个体中欧洲血统与非洲血统的百分比。在调整基因型批次、年龄、体重指数、补充维生素D使用、参与者居住州的紫外线B辐射通量和抽血季节的线性回归分析中，欧洲血统每增加10%与血清维生素D浓度增加0.67 ng/mL相关（95%置信区间：0.17，1.17）。这种关联仅在未服用维生素D补充剂的女性中具有统计学意义（欧洲血统每增加10%，β = 0.86，95%置信区间：0.14，1.57）。在非裔美国人中，使用维生素D补充剂可能有助于减少与遗传祖先相关的维生素D缺乏症。
Circulating levels of vitamin D are generally lower in African Americans than in US whites, and 1 prior analysis carried out in a small number of African Americans suggested that, within this population, vitamin D levels may be related to the degree of genetic admixture. We assessed the association between percentage of European ancestry and serum vitamin D level (assessed in 2013-2015) among 2,183 African-American women from the Black Women's Health Study whose DNA had been genotyped for ancestry-informative markers. ADMIXMAP software was used to estimate the percentage of European ancestry versus African ancestry in each individual. In linear regression analyses with adjustment for genotype batch, age, body mass index, supplemental vitamin D use, ultraviolet B radiation flux in the participant's state of residence, and season of blood draw, each 10% increase in European ancestry was associated with a 0.67-ng/mL increase in serum vitamin D concentration (95% confidence interval: 0.17, 1.17). The association was statistically significant only among women who were not taking vitamin D supplements (for each 10% increase in European ancestry, beta = 0.86, 95% confidence interval: 0.14, 1.57). Among African Americans, use of vitamin D supplements may help to reduce vitamin D deficiency associated with genetic ancestry.