Can Giardia lamblia Infection Lower the Risk of Acute Diarrhea among Preschool Children?
Can Giardia lamblia Infection Lower the Risk of Acute Diarrhea among Preschool Children?
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DOI：
10.1093/tropej/fmt085
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发表时间：
2014-04-01
影响因子：
2
通讯作者：
Levine, Myron M.
中科院分区：
文献类型：
--
作者：
Muhsen, Khitam;Cohen, Dani;Levine, Myron M.
关于蓝氏贾第鞭毛虫在儿童腹泻中的作用，有不一致的发现。一项关于以色列阿拉伯学龄前儿童急性腹泻发病率的前瞻性队列研究提供了机会，以检验蓝氏菌感染(基线)和随后的腹泻之间的联系。在通过光学显微镜对粪便中贾第虫的存在进行基线筛查之后，在2003年10月至2004年8月期间对142名儿童进行了腹泻发生率的跟踪调查。监测是通过母亲面谈进行的。基线时，21名儿童的贾第虫检测呈阳性。在前瞻性监测期间，贾第鞭毛虫阳性儿童急性腹泻发生率(9.5%)低于未感染贾第鞭毛虫儿童(26.5%)。革兰氏杆菌感染与较低的急性腹泻风险相关；调整后的优势比为0.18(95%可信区间为0.04-0.93)(p=0.041)。这项前瞻性研究提供了更多证据，表明贾第虫可能会降低学龄前儿童随后发生急性腹泻的风险。
There are inconsistent findings concerning the role of Giardia lamblia in pediatric diarrhea. A prospective cohort study of the incidence of acute diarrhea among Israeli Arab preschool children offered the opportunity to examine the association between G. lamblia infection (at baseline) and subsequent diarrhea. Following baseline screening by light microscopy for the presence of Giardia in their stools, a cohort was assembled of 142 children who were followed between October 2003 and August 2004 for the incidence of diarrhea. Surveillance was performed through maternal interviews. At baseline, 21 children tested Giardia-positive. During the prospective surveillance, acute diarrhea occurred less often among Giardia-positive children (9.5%) than among children who were not infected with Giardia (26.5%). G. lamblia infection was associated with lower risk of acute diarrhea; adjusted odds ratio of 0.18 (95% confidence interval 0.04-0.93) (p = 0.041). This prospective study provides additional evidence that Giardia may lower the risk of subsequent acute diarrhea among preschool children.