Mobile elements and disease
Mobile elements and disease
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DOI：
10.1016/s0959-437x(98)80092-0
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发表时间：
1998-06-01
影响因子：
4
通讯作者：
Kazazian, HH
中科院分区：
文献类型：
--
作者：
Kazazian, HH
哺乳动物基因组的很大一部分是由可移动元素及其残余物组成的。最近ltr -反转录转座子、非ltr反转录转座子和非自主反转录转座子的插入在小鼠中经常引起疾病，但在人类中很少发生。尽管许多这些元件存在缺陷，但哺乳动物L1型的非ltr逆转录转座子能够自主逆转录。它们逆转录并反过来帮助非自主元件逆转录的机制正在阐明。
A substantial fraction of mammalian genomes is composed of mobile elements and their remnants. Recent insertions of LTR-retrotransposons, non-LTR retrotransposons, and non-autonomous retrotransposons have caused disease frequently in mice, but infrequently in humans. Although many of these elements are defective, a number of mammalian non-LTR retrotransposons of the L1 type are capable of autonomous retrotransposition. The mechanism by which they retrotranspose and in turn aide the retrotransposition of non-autonomous elements is being elucidated.