OpenSAFELY: Representativeness of Electronic Health Record platform OpenSAFELY-TPP data compared to the population of England
OpenSAFELY: Representativeness of Electronic Health Record platform OpenSAFELY-TPP data compared to the population of England
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OpenSAFELY：电子健康记录平台 OpenSAFELY-TPP 数据与英格兰人口相比的代表性
DOI：
10.1101/2022.06.23.22276802
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发表时间：
2022
期刊：
影响因子：
--
通讯作者：
Andrews C
中科院分区：
文献类型：
--
作者：
Andrews C
背景：自2020年3月成立以来，OpenSAFELY-TPP电子健康档案平台的数据已被用于20多项与全球新冠肺炎紧急事件相关的研究。OpenSAFELY-TPP数据来自英国使用SystmOne软件的实践，并已用于这些研究的大部分。我们开始通过将OpenSAFELY-TPP数据与国家人口估计值进行比较来调查其代表性。方法：在英国国民健康保险制度的批准下，我们描述了OpenSAFELY-TPP人口的年龄、性别、多重剥夺指数和种族，与国家统计局的国家估计值相比较。2020年1月1日至2020年12月31日期间发生的五大主要死因也与同期英国登记的死亡人数进行了比较。结果：尽管存在地区差异，但TPP在IMD(均在1.1个百分点以内)、年龄、性别(0.1个百分点以内)、种族和死因方面基本上代表了英格兰的总体人口。五大主要死因的比例与英国国家统计局报告的大致相似(均在1个百分点以内)。结论：通过OpenSAFELY-TPP提供的数据广泛代表了英国人口。OpenSAFELY的用户必须考虑与使用TPP数据进行健康研究相关的代表性、概括性和外部有效性问题。尽管TPP实践的覆盖面在英格兰各地区有所不同，但TPP注册患者在关键人口统计特征方面通常代表了整个英国人口。
Background: Since its inception in March 2020, data from the OpenSAFELY-TPP electronic health record platform has been used for more than 20 studies relating to the global COVID-19 emergency. OpenSAFELY-TPP data is derived from practices in England using SystmOne software, and has been used for the majority of these studies. We set out to investigate the representativeness of OpenSAFELY-TPP data by comparing it to national population estimates. Methods: With the approval of NHS England, we describe the age, sex, Index of Multiple Deprivation and ethnicity of the OpenSAFELY-TPP population compared to national estimates from the Office for National Statistics. The five leading causes of death occurring between the 1st January 2020 and the 31st December 2020 were also compared to deaths registered in England during the same period. Results: Despite regional variations, TPP is largely representative of the general population of England in terms of IMD (all within 1.1 percentage points), age, sex (within 0.1 percentage points), ethnicity and causes of death. The proportion of the five leading causes of death is broadly similar to those reported by ONS (all within 1 percentage point). Conclusions: Data made available via OpenSAFELY-TPP is broadly representative of the English population. Users of OpenSAFELY must consider the issues of representativeness, generalisability and external validity associated with using TPP data for health research. Although the coverage of TPP practices varies regionally across England, TPP registered patients are generally representative of the English population as a whole in terms of key demographic characteristics.