A New Cementless Total Hip Arthroplasty With Bioactive Titanium Porous-Coating by Alkaline and Heat Treatment: Average 4.8-Year Results
A New Cementless Total Hip Arthroplasty With Bioactive Titanium Porous-Coating by Alkaline and Heat Treatment: Average 4.8-Year Results
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DOI：
10.1002/jbm.b.31309
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发表时间：
2009-07-01
影响因子：
3.4
通讯作者：
Matsumoto, Tadami
中科院分区：
文献类型：
--
作者：
Kawanabe, Keiichi;Ise, Kentaro;Matsumoto, Tadami
已经开发了一种通过碱和热处理在钛上形成生物活性涂层的方法，并且表明当浸泡在模拟体液中时，它在植入物表面上形成一层薄薄的羟基磷灰石（HA）。采用这种涂层技术在多孔钛表面进行了一系列70例非骨水泥型初次全髋关节置换术，并对患者进行了平均4.8年的随访。没有松动或翻修的情况，也没有在多孔涂层上形成反应线。尽管术后X线片显示超过70%的病例在宿主骨和窝之间存在间隙，但所有间隙均在一年内消失，表明涂层提供了良好的骨传导。对钛进行碱热处理以提供薄HA涂层与等离子喷涂相比具有若干优点，包括HA涂层不会退化或吸收、制造工艺简单以及成本效益。此外，该方法允许在多孔植入物内均匀沉积骨样磷灰石。尽管这是一项相对短期的研究，但在钛和钛合金植入物上产生生物活性表面的处理对于临床应用具有相当大的希望。(c)2009 Wiley Periodicals，Inc.生物医学材料研究杂志B部分：应用生物材料90 B：476-481，2009
A method has been developed for creating a bioactive coating on titanium by alkaline and heat treatment, and shown that it forms a thin layer of hydroxyapatite (HA) on the surface of implants when soaked in simulated body fluid. A series of 70 cementless primary total hip arthroplasties using this coating technique on a porous titanium surface was performed, and followed up the patients for a mean period of 4.8 years. There were no instances of loosening or revision, or formation of a reactive line on the porous coating. Although radiography just after operation showed a gap between the host bone and the socket in over 70% of cases, all the gaps disappeared within a year, indicating the good osteoconduction provided by the coating. Alkaline-heat treatment of titanium to provide a thin HA coating has several advantages over plasma-spraying, including no degeneration or absorption of the HA coating, simplicity of the manufacturing process, and cost effectiveness. In addition, this method allows homogeneous deposition of bone-like apatite within a porous implant. Although this was a relatively short-term study, treatment that creates a bioactive surface on titanium and titanium alloy implants has considerable promise for clinical application. (c) 2009 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 90B: 476-481, 2009