SKELETAL-MUSCLE SATELLITE CELLS - CHANGES IN PROLIFERATION POTENTIAL AS A FUNCTION OF AGE
SKELETAL-MUSCLE SATELLITE CELLS - CHANGES IN PROLIFERATION POTENTIAL AS A FUNCTION OF AGE
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DOI：
10.1016/0047-6374(82)90105-1
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发表时间：
1982-01-01
影响因子：
5.3
通讯作者：
LIPTON, BH
中科院分区：
文献类型：
--
作者：
SCHULTZ, E;LIPTON, BH
从6日龄至30月龄的SD大鼠比目鱼肌和趾长伸肌分离骨骼肌卫星细胞。并在细胞培养中生长。分别监测每个供体年龄的细胞，以确定它们能够产生的后代数量。在相同的体外条件下，产生的后代的平均数量与供体年龄成反比。卫星细胞的增殖能力随着年龄的增长而下降。
Skeletal muscle satellite cells were isolated from soleus and extensor digitorum longus muscles of Sprague-Dawley rats at selected ages between 6 days and 30 mo. and grown in cell culture. Cells at each donor age were monitored individually to determine the number of progeny they were capable of producing. Under identical in vitro conditions, the average number of progeny produced was inversely proportional to donor age. Proliferation potential of satellite cells decreases with age.