Biocompatible Micelles Based on Comb-like PEG Derivates: Formation, Characterization, and Photo-responsiveness
Biocompatible Micelles Based on Comb-like PEG Derivates: Formation, Characterization, and Photo-responsiveness
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基于梳状 PEG 衍生物的生物相容性胶束：形成、表征和光响应性
DOI：
10.1002/marc.201100196
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发表时间：
2011-07-15
影响因子：
4.6
通讯作者：
Ji, Jian
中科院分区：
文献类型：
--
作者：
Chen, Chao-Jian;Liu, Gong-Yan;Ji, Jian
通过将光响应性 2-重氮-1,2-萘醌 (DNQ) 基团引入梳状聚乙二醇 (CPEG) 结构中，制备了一种新型梳状衍生物 CPEG-g-DNQ。 DLS和TEM结果表明CPEG-g-DNQ在水中自组装成平均尺寸约为135 nm的球形胶束。暴露在光线下时，由于疏水性 DNQ 转化为亲水性 3-茚甲酸，胶束可能会被破坏。此外，疏水性香豆素 102 成功加载到胶束中，并通过荧光光谱法证明了光诱导的开关释放。 MTT 测定表明胶束具有生物相容性。这些光响应胶束可能具有控制疏水性药物释放的巨大潜力。
A novel comb-like derivative CPEG-g-DNQ was prepared by incorporating light responsive 2-diazo-1,2-naphthoquinone (DNQ) groups into the structure of comb-like poly(ethylene glycol) (CPEG). DLS and TEM results showed that CPEG-g-DNQ self-assembled into spherical micelles with an average size of about 135 nm in water. Upon exposure to light, the micelles could be disrupted because of the conversion of hydrophobic DNQ to hydrophilic 3-indenecarboylic acid. Additionally, hydrophobic coumarin 102 was successfully loaded into the micelles and photo-induced ON-OFF release was demonstrated by fluorescence spectroscopy. MTT assay revealed that the micelles are biocompatible. These photo-responsive micelles might have great potential for controlled release of hydrophobic drugs.