Racial and ethnic variations in albuminuria in the US Third National Health and Nutrition Examination Survey (NHANES III) population: Associations with diabetes and level of CKD
Racial and ethnic variations in albuminuria in the US Third National Health and Nutrition Examination Survey (NHANES III) population: Associations with diabetes and level of CKD
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DOI：
10.1053/j.ajkd.2006.07.023
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发表时间：
2006-11-01
影响因子：
13.2
通讯作者：
Young, Bessie A.
中科院分区：
文献类型：
--
作者：
Bryson, Chris L.;Ross, Heather J.;Young, Bessie A.
背景：评估了患有和不患有糖尿病的全国代表性人群中蛋白尿患病率的种族和民族差异。方法：我们分析了第三次全国健康和营养检查调查 (NHANES 111) 的 20,050 名参与者收集的横断面数据，以确定导致微量白蛋白尿和大量白蛋白尿患病率的种族/民族差异的因素。结果：在可获得相关数据的 15,522 名 NHANES III 参与者中，与非西班牙裔白人相比，少数种族/族裔往往更年轻、受教育程度较低、收入较低且拥有保险的可能性较小，这一发现对于患有和未患有糖尿病的人来说是相似的。调整基线协变量和药物使用后，与未患糖尿病的白人相比，患有或未患有糖尿病的种族和族裔出现白蛋白尿的几率更大（患有糖尿病的黑人，调整后的比值比 [aOR]，2.77；95% 置信区间 [CI]，1.46 至 2.72）、患有糖尿病的墨西哥裔美国人（aOR，2.43；95% Cl，1.07 至 2.11）以及其他人群患有糖尿病的种族（aOR，2.93；95% Cl，1.28 至 6.75）。在对潜在混杂因素进行调整后，在非糖尿病患者中，黑人的微量白蛋白尿或大量白蛋白尿的几率是白人的 2.18 倍（95% Cl，1.44 至 3.30），墨西哥裔美国人的微量白蛋白尿或大量白蛋白尿的几率是白人的 1.81 倍（95% Cl，1.08 至 3.02）。按估计肾小球滤过率 (eGFR) 小于 60 mL/min/1.73 m(2) 进行分层（
Background: Racial and ethnic differences in prevalence of albuminuria in a nationally representative population with and without diabetes were assessed. Methods: We analyzed cross-sectional data collected for the 20,050 participants of the Third National Health and Nutrition Examination Survey (NHANES 111) to determine factors that contributed to racial/ethnic differences in microalbuminuria and macroalbuminuria prevalence. Results: For the 15,522 NHANES III participants for whom relevant data were available, racial/ethnic minorities tended to be younger, be less well educated, have lower income, and be less likely to have insurance than non-Hispanic whites, findings that were similar for those with and without diabetes. After adjusting for baseline covariates and medication use, racial and ethnic minorities with and without diabetes had greater odds of alburninuria compared with whites without diabetes (blacks with diabetes, adjusted odds ratio [aOR], 2.77; 95% confidence interval [CI], 1.46 to 2.72), Mexican Americans with diabetes (aOR, 2.43; 95% Cl, 1.07 to 2.11), and those of other ethnicity with diabetes (aOR, 2.93; 95% Cl, 1.28 to 6.75). Of those without diabetes, blacks had 2.18-fold (95% Cl, 1.44 to 3.30) and Mexican Americans had 1.81-fold (95% Cl, 1.08 to 3.02) greater odds of microalbuminuria or macroalbuminuria than whites after adjustment for potential confounding factors. Stratifying by estimated glomerular filtration rate (eGFR) less than 60 mL/min/1.73 m(2) (