T cell immunity to Zika virus targets immunodominant epitopes that show cross-reactivity with other Flaviviruses.
T cell immunity to Zika virus targets immunodominant epitopes that show cross-reactivity with other Flaviviruses.
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针对寨卡病毒的 T 细胞免疫以与其他黄热病病毒有交叉反应的免疫显性表位为目标。
DOI：
10.1038/s41598-017-18781-1
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发表时间：
2018-01-12
影响因子：
4.6
通讯作者：
Altmann DM
中科院分区：
文献类型：
--
作者：
Reynolds CJ;Suleyman OM;Ortega-Prieto AM;Skelton JK;Bonnesoeur P;Blohm A;Carregaro V;Silva JS;James EA;Maillère B;Dorner M;Boyton RJ;Altmann DM
寨卡病毒（ZIKV）感染有几种结果，来自无症状暴露于皮疹、结膜炎、格林-巴利综合征或先天性寨卡综合征。ZIKV免疫的分析被几种相关的黄病毒感染人类的事实所混淆，包括登革热病毒1-4、西尼罗河病毒和黄热病病毒。ZIKV和其他黄病毒感染或疫苗接种之间的HLA II类限制性T细胞交叉反应性可能有助于保护或增强免疫病理学。我们在HLA II类转基因小鼠中定位了来自ZIKV包膜（Env）的免疫显性、HLA II类限制性、CD 4表位以及非结构（NS）NS 1、NS 3和NS 5抗原。在几种情况下，ZIKV引发的CD 4细胞对来自其他病毒的同源序列产生应答，包括DENV 1 -4、WNV或YFV。然而，交叉反应性应答可赋予免疫偏离-对HLA-DR 1中Env DENV 4 p1表位的应答导致IL-17 A免疫，通常与加重的免疫发病机制相关。跨黄病毒的这种识别保守性可包括保护性和/或致病性组分，并对ZIKV保护性免疫的表征提出挑战。
Zika virus (ZIKV) Infection has several outcomes from asymptomatic exposure to rash, conjunctivitis, Guillain-Barré syndrome or congenital Zika syndrome. Analysis of ZIKV immunity is confounded by the fact that several related Flaviviruses infect humans, including Dengue virus 1–4, West Nile virus and Yellow Fever virus. HLA class II restricted T cell cross-reactivity between ZIKV and other Flaviviruses infection(s) or vaccination may contribute to protection or to enhanced immunopathology. We mapped immunodominant, HLA class II restricted, CD4 epitopes from ZIKV Envelope (Env), and Non-structural (NS) NS1, NS3 and NS5 antigens in HLA class II transgenic mice. In several cases, ZIKV primed CD4 cells responded to homologous sequences from other viruses, including DENV1–4, WNV or YFV. However, cross-reactive responses could confer immune deviation - the response to the Env DENV4 p1 epitope in HLA-DR1 resulted in IL-17A immunity, often associated with exacerbated immunopathogenesis. This conservation of recognition across Flaviviruses, may encompass protective and/or pathogenic components and poses challenges to characterization of ZIKV protective immunity.
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影响因子：
6.7
作者：
Pardy RD;Rajah MM;Condotta SA;Taylor NG;Sagan SM;Richer MJ
通讯作者：
Richer MJ
影响因子：
30.5
作者：
Dejnirattisai W;Supasa P;Wongwiwat W;Rouvinski A;Barba-Spaeth G;Duangchinda T;Sakuntabhai A;Cao-Lormeau VM;Malasit P;Rey FA;Mongkolsapaya J;Screaton GR
通讯作者：
Screaton GR
影响因子：
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作者：
Manangeeswaran M;Ireland DD;Verthelyi D
通讯作者：
Verthelyi D
影响因子：
32.4
作者：
NICHOLSON, LB;GREER, JM;KUCHROO, VK
通讯作者：
KUCHROO, VK
影响因子：
15.9
作者：
Novak, EJ;Liu, AW;Kwok, WW
通讯作者：
Kwok, WW