Late sympathetic reinnervation and normalization of canine myocardial beta-adrenergic receptor density following denervation.
Late sympathetic reinnervation and normalization of canine myocardial beta-adrenergic receptor density following denervation.
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发表时间：
1995-09
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通讯作者：
H. Valette;A. Syrota;P. Deleuze;C. Crouzel;J. Delforge;C. Fuseau;D. Loisance
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作者：
H. Valette;A. Syrota;P. Deleuze;C. Crouzel;J. Delforge;C. Fuseau;D. Loisance
格罗斯等人展示的令人印象深刻的一系列肾上腺图像中似乎存在一些轻微的算术错误。 (1) 例如，文章提到了 44 种肾上腺内肿瘤，而原始文章表 1 中只列出了 43 种。同样，表2中提到了14例正常形态的腺瘤，而文字暗示只有12例。最后，腺瘤的数量给出的不一致，为185或171。但更重要的是，在数据分析中出现了错误。作者将真阴性定义为腺瘤成像的一致模式或肾上腺周围假肾上腺肿块的正常模式。这意味着影像学检查是根据破坏性肾上腺病变的诊断来判断的。然而，在这种情况下，产生对称图像的 14 个腺瘤不能被视为假阴性，而应被视为真阴性，因为这些病例的扫描不会引起破坏性病变的怀疑。换句话说，即使这些腺瘤被错误地分类为正常，它们作为无破坏性肾上腺病变的病例的分类是正确的。表 1 给出了考虑这些变化时获得的测试参数值。如果测试的目的是诊断腺瘤或是否存在任何肾上腺病变，则可以进行替代分析。表1中还给出了相应的测试参数。可以看出，根据测试目的，阴性预测值有很大不同。不存在不一致模式（破坏性病变阴性测试）高度预测不存在破坏性病变（98%），而不存在破坏性病变则可高度预测（98%）。
TO THE EDflOR Some slight arithmeticerrors seem to have slipped into the otherwise impressive series of adrenal images presentedby Gross et al. (1) For instance, the articlementions44 intra-adrenal neoplasms, whereas only 43 are represented in Table 1 of the original article. Similarly, 14 cases of adenoma with normalpatternsarementionedin Table2, whereasthe text im plies that there are only 12.Finally, the numberof adenomasis inconsistently given as 185or 171. Moreimportant, however,anerrorwas madeindataanalysis. The authorsdefinetrue-negativeas a concordantpatternof imag ingin adenomaor a normalpattern in periadrenalor pseudoadre nal masses. This impliesthat the imagingtest is beingjudged with respect to the diagnosis of destructive adrenal lesions. In that case, however, the 14 adenomas which yielded symmetrical im ages can not be considered as false-negativesbut should be viewed as true-negatives,because the scans in these cases do not raise the suspicionof a destructivelesion.In otherwords, even if these adenomasare misclassifiedas normal,theirclassificationas cases without destructive adrenal lesions is correct. Table 1 gives the values for the test parametersthat are obtained when these changes are considered. Alternative analyses can be performed if the aim of the test is to diagnose adenoma or the presence of any adrenallesion. The corresponding test parameters are also given in Table 1. As can be seen, the negative predictivevalue is quite differentaccordingto the purpose of the test. The absence of a discordant pattern (negative test for destructive lesion) is highlypredictive (98%)for the absence of a destructive lesion, whereas the absence of a