Relationship between photoreceptor outer segment length and visual acuity in diabetic macular edema.
Relationship between photoreceptor outer segment length and visual acuity in diabetic macular edema.
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DOI：
10.1097/iae.0b013e3181bd2c5a
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发表时间：
2010-01
期刊：
影响因子：
--
通讯作者：
Ferris FL 3rd
中科院分区：
文献类型：
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作者：
Forooghian F;Stetson PF;Meyer SA;Chew EY;Wong WT;Cukras C;Meyerle CB;Ferris FL 3rd
应用光谱域光学相干断层扫描(OCT)对糖尿病黄斑水肿(DME)患者的光感受器外段(PROS)长度进行量化，并描述该组患者PROS长度与视力的相关性。前瞻性研究。27例(30只眼)DME患者。在每次治疗期间，使用Cirrus™HD-OCT对所有眼睛进行三次SD-OCT扫描。开发了一种用于职业长度定量评估的原型算法。计算黄斑网格点(6 mm×6 mm)、中央亚野(1 Mm)和中心凹中心点(0.33 mm)三个参数的视网膜厚度和长度。用变异系数(CVW)和组内相关系数(ICC)评价插管内的重复性。用线性回归和皮尔逊相关分析评估视网膜厚度和长度与视力的关系。黄斑参数的可重复性，以及这些参数与视力的相关性。黄斑参数的平均视网膜厚度为2 98~3 81μm，平均视网膜长度为30~32μm。视网膜厚度CVW值为0.75~4.13%，长度CVW值为1.97~14.01%。视网膜厚度和长度的IC值分别为0.96~0.99和0.73~0.98。评估视网膜厚度和视力相关性的线性回归分析的斜率与零没有显著差异(p>；0.0005)，而专业长度和视力的斜率与零有显著差异(p<；0.2)。黄斑厚度和视力的相关系数在0.13到0.22之间，而专业长度和视力的相关系数在-0.61到-0.81之间。PROS长度可以使用Cirrus™HD-OCT进行定量评估。虽然PROS测量的可重复性低于黄斑厚度测量，但PROS长度与视力的相关性更强，提示PROS测量可能与视功能更直接相关。无论是在临床上还是作为治疗效果的直接评估，PROS长度都可能是一个有用的生理学结果指标。
To quantify photoreceptor outer segment (PROS) length in patients with diabetic macular edema (DME) using spectral domain optical coherence tomography (OCT), and to describe the correlation between PROS length and visual acuity in this group of patients. Prospective study. Twenty-seven consecutive patients (30 eyes) with DME. Three SD-OCT scans were performed on all eyes during each session using Cirrus™ HD-OCT. A prototype algorithm was developed for quantitative assessment of PROS length. Retinal thicknesses and PROS lengths were calculated for three parameters; macular grid (6mm × 6mm), central subfield (1mm), and center foveal point (0.33mm). Intrasession repeatability was assessed using coefficient of variation (CVW) and intraclass correlation coefficient (ICC). Association between retinal thickness and PROS length with visual acuity was assessed using linear regression and Pearson correlation analyses. Intrasession repeatability of macular parameters, and correlation of these parameters with visual acuity. Mean retinal thickness and PROS length were 298-381 μm and 30-32 μm, respectively, for macular parameters assessed in this study. CVW values were 0.75-4.13% for retinal thickness, and 1.97-14.01% for PROS length. ICC values were 0.96-0.99 and 0.73-0.98 for retinal thickness and PROS length, respectively. Slopes from linear regression analyses assessing the association of retinal thickness and visual acuity were not significantly different from zero (p>0.20), whereas the slopes of PROS length and visual acuity were significantly different from zero (p<0.0005). Correlation coefficients for macular thickness and visual acuity ranged from 0.13 to 0.22, while coefficients for PROS length and visual acuity ranged from -0.61 to -0.81. PROS length can be quantitatively assessed using Cirrus™ HD-OCT. Although the intrasession repeatability of PROS measurements was less than that of macular thickness measurements, the stronger correlation of PROS length with visual acuity suggests that PROS measures may be more directly related to visual function. PROS length may be a useful physiologic outcome measure, both clinically and as a direct assessment of treatment effects.