Comparisons of Clinical Features in Japanese Patients with Beh?et’s Uveitis Treated in the 1990s and the 2000s
Comparisons of Clinical Features in Japanese Patients with Beh?et’s Uveitis Treated in the 1990s and the 2000s
复制标题
20 世纪 90 年代与 2000 年代日本白塞氏葡萄膜炎患者临床特征比较
DOI：
10.1080/09273948.2018.1559928
复制
发表时间：
2019
影响因子：
3.3
通讯作者：
Aihara Makoto
中科院分区：
文献类型：
--
作者：
Nakahara Hisae;Kaburaki Toshikatsu;Tanaka Rie;Yoshida Atsushi;Takamoto Mitsuko;Kawata Mikiko;Fujino Yujiro;Kawashima Hidetoshi;Aihara Makoto
目的：方法：回顾性分析20世纪90年代和21世纪初收治的68例眼白塞病患者的临床资料，并与20世纪90年代收治的107例眼白塞病患者进行比较。患者特征、眼部和全身症状、眼部发作频率、24-6个月BD眼部发作评分观察两组患者的BOS 24 - 6 M、最佳矫正视力（BCVA）和免疫调节治疗情况。21世纪初的临床特征显示，虹膜睫状体炎类型、肠、血管和神经BD病例、口服皮质类固醇、甲氨蝶呤和英夫利西单抗治疗使用增加，白内障和青光眼手术以及人工晶状体，以及减少BOS 24 - 6 M和环磷酰胺的使用。结论：2000年以后，患者的眼部BD倾向较轻，但特殊类型BD的发生率可能增加。
Purpose: We investigated clinical characteristics of ocular Behçet’s disease (BD) patients treated in the 1990s and the 2000s.Methods: We retrospectively examined records of 68 newly arrived patients with ocular BD followed for more than 4 months during the 2000s and compared to those of 107 patients during the 1990s. Patient profiles, ocular and systemic symptoms, frequency of ocular attacks, BD ocular attack score 24–6 months (BOS24-6M), best-corrected visual acuity (BCVA), and immunomodulatory treatment were noted.Results: Clinical characteristics in the 2000s showed increases in iridocyclitis type, intestinal-, vasculo-, and neuro-BD cases, oral corticosteroid, methotrexate, and infliximab therapy usage, cataract and glaucoma surgery, and pseudophakia, and decreases in BOS24-6M and cyclophosphamide usage. BCVA of 20/30 or better at the final visit was slightly increased in the 2000s.Conclusions: Milder ocular BD tendency was seen in cases in the 2000s, whereas the incidence of special type of BD might be increasing.