A relationship between behavior, neurotrophin expression, and new neuron survival
A relationship between behavior, neurotrophin expression, and new neuron survival
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DOI：
10.1073/pnas.140222497
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发表时间：
2000-07-18
影响因子：
11.1
通讯作者：
Nottebohm, F
中科院分区：
文献类型：
--
作者：
Li, XC;Jarvis, ED;Nottebohm, F
高级发声中枢(HVC)控制鸣禽的鸣叫产生，并向下行发声通路的粗壮的弓状核(RA)发送投射。HVC在成年期接受新的神经元。大多数新神经元投射到RA，并取代其他同类神经元。我们在这里表明，歌唱增强了成年雄性金丝雀(Serinus Canaria)HVC中脑源性神经营养因子(BDNF)的mRNA和蛋白表达。BDNF表达的增加与单位时间产生的歌曲数量成正比。歌唱诱导的BDNF在HVC的表达主要发生在RA投射神经元。在注射BrdUrd后31-38天，比较了不唱歌和不唱歌的鸟类的神经元存活率。在会唱歌的鸟儿中，新HVC神经元的存活率比在不会唱歌的鸟儿中更大。在成年后招募新神经元的系统中，通路的使用、神经营养因子的表达和新神经元存活之间的正向因果联系可能是常见的。
The high vocal center (HVC) controls song production in songbirds and sends a projection to the robust nucleus of the archistriatum (RA) of the descending vocal pathway. HVC receives new neurons in adulthood. Most of the new neurons project to RA and replace other neurons of the same kind. We show here that singing enhances mRNA and protein expression of brain-derived neurotrophic factor (BDNF) in the HVC of adult male canaries, Serinus canaria. The increased BDNF expression is proportional to the number of songs produced per unit time. Singing-induced BDNF expression in HVC occurs mainly in the RA-projecting neurons. Neuronal survival was compared among birds that did or did not sing during days 31-38 after BrdUrd injection. Survival of new HVC neurons is greater in the singing birds than in the nonsinging birds. A positive causal link between pathway use, neurotrophin expression, and new neuron survival may be common among systems that recruit new neurons in adulthood.