SEPARATE AND COMBINED EFFECTS OF THE SOCIAL DRUGS ON PSYCHOMOTOR PERFORMANCE
SEPARATE AND COMBINED EFFECTS OF THE SOCIAL DRUGS ON PSYCHOMOTOR PERFORMANCE
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DOI：
10.1007/bf02244564
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发表时间：
1991-01-01
影响因子：
3.4
通讯作者：
HINDMARCH, I
中科院分区：
文献类型：
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作者：
KERR, JS;SHERWOOD, N;HINDMARCH, I
10名女性受试者在给予尼古丁的每种可能的组合后4小时内，在设定点上测试（5名吸烟者和5名非吸烟者）的选择反应时任务（CRT）、补偿跟踪任务（CTT）、短时记忆任务（STM），并测试其临界闪烁融合阈值（CFF）。（2毫克口香糖或安慰剂），咖啡因（250毫克胶囊或安慰剂）和酒精（30克或安慰剂）。尼古丁或咖啡因能促进记忆和运动功能，而酒精的衰弱作用经常被这两种药物所拮抗。尽管尼古丁、咖啡因和酒精的神经药理学作用存在差异，但可以通过它们对涉及精神表现的常见信息处理机制的影响来比较尼古丁、咖啡因和酒精的组合。
Ten female subjects (five smokers and five nonsmokers) performed a choice reaction time task (CRT), a compensatory tracking task (CTT), a short-term memory task (STM) and were tested for their critical flicker fusion threshold (CFF) at set points over 4 h after the administration of each possible combination of nicotine (2 mg gum or placebo), caffeine (250 mg capsule or placebo) and alcohol (30 g or placebo). Memory and motor function were shown to be facilitated by nicotine or caffeine, and the debilitating effects of alcohol were frequently antagonised by either drug. In spite of the differences in their neuropharmacological actions, combinations of nicotine, caffeine and alcohol may be compared through their effects on common information processing mechanisms involved in psychomotor performance.