The blunting of the antiproteinuric efficacy of ACE inhibition by high sodium intake can be restored by hydrochlorothiazide
The blunting of the antiproteinuric efficacy of ACE inhibition by high sodium intake can be restored by hydrochlorothiazide
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DOI：
10.1093/ndt/13.7.1682
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发表时间：
1998-07-01
影响因子：
6.1
通讯作者：
de Zeeuw, D
中科院分区：
文献类型：
--
作者：
Buter, H;Hemmelder, MH;de Zeeuw, D
背景。限制饮食钠可增强 ACE 抑制的抗蛋白尿和降血压作用。然而，在临床实践中，长期遵守低钠饮食可能很难。因此，我们研究了是否可以通过添加利尿剂来恢复高钠摄入导致的 ACE 抑制的抗蛋白尿和降血压功效的减弱。患者和方法。对 7 名患有非糖尿病肾病的蛋白尿患者进行了三个连续 4 周期间的慢性 ACE 抑制研究：低钠（50 mmol/天）、高钠（200 mmol/天）和高钠加氢氯噻嗪（50 mg o.i.d.）。结果。低钠摄入期间，蛋白尿为 3.1 (0.7-5.2) g/天，高钠摄入期间，蛋白尿增加至 4.5 (1.6-9.2) g/天 (P
Background. Dietary sodium restriction enhances the antiproteinuric and blood pressure lowering effect of ACE inhibition. In clinical practice, however, long-term compliance to a low-sodium diet may be difficult to obtain. We therefore investigated whether the blunting of the antiproteinuric and blood pressure lowering efficacy of ACE inhibition by high sodium intake can be restored by the addition of a diuretic.Patients and methods. Seven proteinuric patients with non-diabetic renal disease on chronic ACE inhibition were studied during three consecutive 4-week periods: low sodium (50 mmol/day), high sodium (200 mmol/day) and high sodium plus hydrochlorothiazide (50 mg o.i.d.).Results. During low sodium intake proteinuria was 3.1 (0.7-5.2) g/day, during high sodium intake proteinuria increased to 4.5 (1.6-9.2)g/day (P