Comparison of circulating adiponectin and proinflammatory markers regarding their association with metabolic syndrome in Japanese men
Comparison of circulating adiponectin and proinflammatory markers regarding their association with metabolic syndrome in Japanese men
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DOI：
10.1161/01.atv.0000208363.85388.8f
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发表时间：
2006-04-01
影响因子：
8.7
通讯作者：
Toyoshima, H
中科院分区：
文献类型：
--
作者：
Matsushita, K;Yatsuya, H;Toyoshima, H
背景-抗炎和促炎分子据称在代谢综合征(METS)的发生中起着重要作用。方法和结果：我们研究了624名没有心血管疾病或癌症病史的日本中年男性，调查了循环肿瘤坏死因子-α(TNF-α)、白介素6(IL-6)、C反应蛋白(CRP)和脂联素与METS的关系。我们使用了由国家胆固醇教育计划成人治疗小组III(ATP-III)、国际糖尿病联合会和日本内科学会提出的各自的定义。血清脂联素水平在有任何一种三磷酸腺苷-III-蛋氨酸成分的患者中观察到降低，而在肿瘤坏死因子-α、IL-6或C反应蛋白升高的患者中则不是这样。脂联素和C反应蛋白水平随着三磷酸腺苷-III-蛋氨酸组分的增加而线性恶化(趋势分别为P<；0.001)。在符合任何METS标准的患者中，观察到显著较高的CRP和较低的脂联素水平，而仅在那些ATP-III-METS患者中观察到肿瘤坏死因子-α的升高。最后，用多因素Logistic回归分析计算对数转换后的4个标记物1-SD增加/减少的METS患病率的优势比(OR)。因此，脂联素降低与三磷酸腺苷-Ⅲ-蛋氨酸(脂联素：OR，1.9[95%CI，1.44至2.51]；P<；0.001；C反应蛋白：OR，1.33[95%CI，1.01至1.74]；P=0.03；肿瘤坏死因子-α：OR，1.2 5[95%CI，0.94至1.67]；P=0.12；IL-6：OR，0.87[95%CI，0.63至1.19]；P=0.37)的相关性最强。这一结果不会被其他两个标准改变。结论--目前的结果提出了血清脂联素降低可能是蛋氨酸综合征发生的根本原因。
Background-Anti-inflammatory and proinflammatory molecules purportedly play an important role in developing metabolic syndrome (MetS). However, little is known as to the relative importance of these molecules in the association with MetS.Methods and Results-We studied 624 middle-aged Japanese men without medical history of cardiovascular disease or cancer and investigated the associations of circulating tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), C-reactive protein (CRP), and adiponectin with MetS. We used the respective definitions proposed by the National Cholesterol Education Program Adult Treatment Panel III (ATP-III), the International Diabetes Federation, and the Japanese Society of Internal Medicine. Decreased serum adiponectin was observed in those with any of the ATP-III - MetS components, whereas this was not the case with increased TNF-alpha, IL-6, or CRP. Adiponectin and CRP levels linearly deteriorated with an increasing number of ATP-III-MetS components (trend P < 0.001, respectively). Significantly higher CRP and lower adiponectin levels were observed in those who met any MetS criteria, whereas increased TNF-alpha was observed in only those with ATP- III - MetS. Finally, odds ratios (ORs) for MetS prevalence of a 1-SD increase/decrease in log-transformed 4 markers were calculated with multivariate logistic regression analyses. Consequently, decreased adiponectin was associated most strongly with ATP- III - MetS (adiponectin: OR, 1.90 [95% CI, 1.44 to 2.51]; P < 0.001; CRP: OR, 1.33 [95% CI, 1.01 to 1.74]; P = 0.03; TNF-alpha: OR, 1.25 [95% CI, 0.94 to 1.67]; P = 0.12; and IL-6: OR, 0.87 [95% CI, 0.63 to 1.19]; P = 0.37). This result was not altered by using the other 2 criteria.Conclusions-The present results raise the possibility that decreased serum adiponectin might be fundamentally involved in the development of MetS.