BENIGN PROSTATIC HYPERPLASIA SPECIFIC HEALTH-STATUS MEASURES IN CLINICAL RESEARCH - HOW MUCH CHANGE IN THE AMERICAN-UROLOGICAL-ASSOCIATION SYMPTOM INDEX AND THE BENIGN PROSTATIC HYPERPLASIA IMPACT INDEX IS PERCEPTIBLE TO PATIENTS
BENIGN PROSTATIC HYPERPLASIA SPECIFIC HEALTH-STATUS MEASURES IN CLINICAL RESEARCH - HOW MUCH CHANGE IN THE AMERICAN-UROLOGICAL-ASSOCIATION SYMPTOM INDEX AND THE BENIGN PROSTATIC HYPERPLASIA IMPACT INDEX IS PERCEPTIBLE TO PATIENTS
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DOI：
10.1016/s0022-5347(01)66780-6
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发表时间：
1995-11-01
影响因子：
6.6
通讯作者：
LEPOR, H
中科院分区：
文献类型：
--
作者：
BARRY, MJ;WILLIFORD, WO;LEPOR, H
目的：在一项比较不同药物治疗良性前列腺增生症的大型退伍军人事务试验中，我们评估了美国泌尿系协会(AUA)症状指数和良性前列腺增生症(BPH)影响指数评分的变化与患者整体改善评分的关系。材料和方法：初步分析比较了1,218名男性在13周时从基线到全球改善评分的绝对分数变化。结果：自评为轻微改善的受试者，AUA症状指数和BPH影响指数评分分别平均下降3.1和0.4分。结论：这些数据为研究者使用AUA症状指数和BPH影响指数作为结果衡量标准提供了指导。
Purpose: We assessed the relationship between changes in scores for the American Urological Association (AUA) symptom index and benign prostatic hyperplasia (BPH) impact index with patient global ratings of improvement in a large Veterans Affairs trial comparing different pharmacological therapies for BPH.Materials and Methods: The primary analyses compared absolute score changes from baseline with global ratings of improvement-at 13 weeks for 1,218 men.Results: Subjects who rated themselves as being slightly improved had a mean decrease in AUA symptom index and BPH impact index scores of 3.1 and 0.4 points, respectively. However, the baseline scores strongly influenced this relationship.Conclusions: These data provide guidance for investigators using the AUA symptom index and BPH impact index as outcome measures.