Behcet's disease in Japan and in Great Britain: a comparative study
Behcet's disease in Japan and in Great Britain: a comparative study
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DOI：
10.1076/0927-3948(200009)8:3;1-k;ft141
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发表时间：
2000-01-01
影响因子：
3.3
通讯作者：
Towler, HMA
中科院分区：
文献类型：
--
作者：
Muhaya, M;Lightman, S;Towler, HMA
白塞氏病 (BD) 是全世界视觉发病的重要原因，但在种族偏好方面表现出显着差异。尽管急性眼内炎症的治疗管理取得了重要进展，但这些新策略对 BD 视力结果的长期影响及其在不同种族群体中的疗效尚不清楚。对符合白塞氏病国际研究组和日本白塞氏病研究委员会标准的所有患者进行了患者特征、临床眼部特征和炎症评分以及当前治疗的比较研究，这些患者连续 4 周期间到 Moorfields 眼科医院 (n = 19) 和久留米大学医学院 (KUS) (n = 35) 葡萄膜炎诊所就诊。日本患者的年龄（43.2 +/- 11.8 岁）明显高于伦敦患者（35.4 +/- 8.9 岁）。两组患者均以男性患者为主。 KUS 看到的所有患者都是日本人，而伦敦的患者包括 12 名白种人、5 名中东人、1 名非洲人和 1 名亚洲人。两个人群的全身性疾病或受疾病影响的系统（例如口腔溃疡、生殖器溃疡、皮肤病变（包括结节性红斑）或关节炎）的持续时间没有显着差异。两个中心的眼部疾病持续时间相似：大约七年。然而，患有活动性前葡萄膜炎（59.7% KUS vs 18.4% London（卡方：5.4；p=0.006））和/或后葡萄膜炎（31.3% KUS vs 18.4% London（卡方：5.42；p=0.006））的眼睛数量存在显着差异。
Behcet's disease (BD) is an important cause of visual morbidity throughout the world, but shows striking differences in racial predilection. Despite important advances in the therapeutic management of acute intraocular inflammation, the long-term impact of these new strategies on visual outcome of BD and their efficacy in different ethnic groups is unknown. A comparative study of patient characteristics, clinical ocular features and inflammatory score, and current therapy was undertaken on all patients fulfilling the International Study Group criteria for Behcet's disease and the Behcet's Disease Research Committee of Japan, who attended the Uveitis Clinics of Moorfields Eye Hospital (n = 19) and Kurume University School of Medicine (KUS) (n = 35) during a continuous consecutive four-week period. Japanese patients were significantly older (43.2 +/- 11.8 years) than the patients seen in London (35.4 +/- 8.9 years). There was a predominance of male patients in both groups. All patients seen in KUS were Japanese, while the patients in London included 12 Caucasians, five Middle Eastern, one African, and one Asian. No significant differences were seen between the two populations in the duration of systemic disease or systems affected by the disease, such as mouth ulcers, genital ulcers, skin lesions including erythema nodosum, or arthritis. The duration of ocular disease was similar in both centres: around seven years. There was, however, a significant difference in the number of eyes with active anterior uveitis (59.7% KUS vs 18.4% London (chi-square: 5.4; p=0.006)) and/or posterior uveitis (31.3% KUS vs 18.4% London (chi-square: 5.42; p