Binaural processing deficit and cognitive impairment in Alzheimer's disease
Binaural processing deficit and cognitive impairment in Alzheimer's disease
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Alzheimer病患者的双耳加工缺陷与认知功能损害
DOI：
10.1002/alz.12464
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发表时间：
2021-09-27
影响因子：
14
通讯作者：
Tang, Yi
中科院分区：
文献类型：
--
作者：
Wang, Changming;Wang, Zhibin;Tang, Yi
嘈杂环境下的言语理解依赖于中枢听觉功能，而中枢听觉功能在阿尔茨海默病（AD）中是脆弱的。双耳处理利用双耳声音对退化的声音信息进行最佳处理；其特征在AD中了解甚少。我们研究了121名参与者（AD = 27；遗忘性轻度认知障碍[aMCI] = 33；主观认知衰退[SCD] = 30；认知正常[CN] = 31）双耳加工的行为和电生理改变。我们观察到AD和aMCI双耳加工的损伤，并检测到相位同步的u型曲线变化（从CN到SCD再到aMCI下降，但从aMCI到AD增加）。随着认知阶段的加重，相同步的改善可能反映了神经对双耳加工的适应。此外，在神经适应明显发生的阶段，相同步的增加与较差的记忆有关。这些发现支持了一种假设，即双耳加工缺陷的神经适应可能会加剧认知障碍，这可能有助于识别AD的生物标志物和治疗靶点。
Speech comprehension in noisy environments depends on central auditory functions, which are vulnerable in Alzheimer's disease (AD). Binaural processing exploits two ear sounds to optimally process degraded sound information; its characteristics are poorly understood in AD. We studied behavioral and electrophysiological alterations in binaural processing among 121 participants (AD = 27; amnestic mild cognitive impairment [aMCI] = 33; subjective cognitive decline [SCD] = 30; cognitively normal [CN] = 31). We observed impairment of binaural processing in AD and aMCI, and detected a U-shaped curve change in phase synchrony (declining from CN to SCD and to aMCI, but increasing from aMCI to AD). This improvement in phase synchrony accompanying more severe cognitive stages could reflect neural adaptation for binaural processing. Moreover, increased phase synchrony is associated with worse memory during the stages when neural adaptation apparently occurs. These findings support a hypothesis that neural adaptation for binaural processing deficit may exacerbate cognitive impairment, which could help identify biomarkers and therapeutic targets in AD.