Synthesis of hydroxyl silylated rhenium and (99mTc)technetium ‘3+1’ mixed ligand complexes
Synthesis of hydroxyl silylated rhenium and (99mTc)technetium ‘3+1’ mixed ligand complexes
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羟基硅烷化铼与(99mTc)锝‘3+1’混合配体配合物的合成
DOI：
10.1002/jlcr.567
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发表时间：
2002
期刊：
影响因子：
--
通讯作者：
Alla Zablotska
中科院分区：
文献类型：
--
作者：
T. Kniess;H. Spies;I. Santos;Alla Zablotska
描述了作为单齿配体的羟基甲硅烷基化硫醇的合成。这些单齿化合物被用来与 Re 和 99mTc 三甲基、三乙基和三苯基甲硅烷基化的“3+1”混合配体配合物一起构建，并使用 3thiapentane-1,5-dithiol 作为共配体。 Re配合物通过1H NMR和元素分析进行表征，99mTc配合物通过放射性HPLC检测。虽然三甲基甲硅烷基化衍生物在水介质中水解，但三乙基和三苯基甲硅烷基化络合物已被证明在中性溶液中是稳定的。版权所有 © 2002 约翰威利父子有限公司
The synthesis of hydroxyl silylated thiols as monodentate ligands is described. These monodentates were used to build with Re and 99mTc trimethyl-, triethyl- and triphenyl-silylated ‘3+1’ mixed ligand complexes, using 3thiapentane-1,5-dithiol as co-ligand. The Re complexes were characterized by 1H NMR and elemental analysis, the 99mTc complexes were detected by radio HPLC. While the trimethyl silylated derivatives hydrolysed in aqueous media, the triethyl- and triphenyl silylated complexes have proved to be stable in neutral solutions. Copyright © 2002 John Wiley & Sons, Ltd.