Navigation using indocyanine green fluorescence imaging for hepatoblastoma pulmonary metastases surgery
Navigation using indocyanine green fluorescence imaging for hepatoblastoma pulmonary metastases surgery
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DOI：
10.1007/s00383-015-3679-y
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发表时间：
2015-04-01
影响因子：
1.8
通讯作者：
Ohtsubo, Seiji
中科院分区：
文献类型：
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作者：
Kitagawa, Norihiko;Shinkai, Masato;Ohtsubo, Seiji
为了实现对化疗耐药性肝母细胞瘤肺转移的精确、灵敏检测，我们使用吲哚菁绿（ICG）荧光成像导航进行手术。对 10 名 1 岁至 11 岁的患者进行了肺转移切除术。术前24 h静脉注射ICG（0.5 mg/kg）。进行开胸手术后，使用发生器将 760 nm 红外线照射到肺部，收集 830 nm 诱发荧光并在实时显示器上可视化。 37 次手术总共切除了 250 个荧光阳性病灶。所有病理学阳性病变均明显荧光阳性。可检测到的最小病灶直径为 0.062 毫米。两名患者中有29个被切除的病灶，经病理证实不是肝母细胞瘤转移。尽管仍然存在假阳性问题，但该方法对于检测小型肺转移瘤非常有用。
To achieve precise and sensitive detection of chemotherapy-resistant hepatoblastoma pulmonary metastases, we performed surgery using indocyanine green (ICG) fluorescence imaging navigation. Lung metastasectomies were performed in 10 patients aged from 1 to 11 years. ICG (0.5 mg/kg) was injected intravenously 24 h before the operation. After a thoracotomy had been performed, a 760-nm infrared ray was applied to the lung using a generator and the 830-nm evoked fluorescence was collected and visualized on a real-time display. In total, 250 fluorescence-positive lesions were extirpated in 37 operations. All of the pathologically positive lesions were clearly fluorescence positive. The diameter of the smallest detectable lesion was 0.062 mm. In two patients, there were 29 extirpated lesions that were pathologically proven not to be hepatoblastoma metastases. Although a problem of false positive remains, this method is very useful for the detection of small pulmonary metastases.