[Toxicological studies on (2''R)-4'-O-tetrahydropyranyladriamycin, a new antitumor antibiotic. Acute toxicity study in mice].
[Toxicological studies on (2''R)-4'-O-tetrahydropyranyladriamycin, a new antitumor antibiotic. Acute toxicity study in mice].
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新型抗肿瘤抗生素(2R)-4-O-四氢吡喃霉素的毒理学研究。
DOI：
10.11553/antibiotics1968b.39.250
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发表时间：
1986
期刊：
影响因子：
--
通讯作者：
H. Kumagai
中科院分区：
文献类型：
--
作者：
H. Tone;M. Shirai;F. Onoue;H. Kumagai
本文报道了一种新的抗肿瘤蒽环类抗生素：（2 '' R）-4 '-O-四氢吡喃阿霉素盐酸盐（THP）经不同途径给药对ddY小鼠的急性毒性研究。根据14天观察期内的死亡率计算LD 50值，静脉注射时为14-21 mg/kg，腹腔注射或皮下注射给药途径，口服给药时为420-570 mg/kg。给药后，小鼠表现出自发活动抑制、厌食、腹泻和轻微脱发。对被该药杀死的小鼠进行的尸检显示，胸腺、脾脏、睾丸、子宫和卵巢萎缩，肠道充血和出血。然而，在观察期内存活的小鼠仅显示胸腺和性器官萎缩。
A new antitumor anthracycline antibiotic; (2''R)-4'-O-tetrahydropyranyladriamycin hydrochloride (THP) was administered to ddY mice via different routes for acute toxicity studies. The LD50 values were calculated from mortality rates during a 14-day observation period, and were 14-21 mg/kg when i.v., i.p. or s.c. route was used and 420-570 mg/kg when the drug was given p.o. Upon administration of the drug, mice showed depression of spontaneous activity, anorexia, diarrhea and slight alopecia. Autopsy of the mice killed by the drug revealed atrophy of thymus, spleen, testes, uterus and ovaries, and congestion and hemorrhage in the intestines. The mice which survived through the observation period, however, showed only atrophy of thymus and sexual organs.