Aberrant epigenetic regulation of bromodomain Brd4 in human colon cancer
Aberrant epigenetic regulation of bromodomain Brd4 in human colon cancer
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DOI：
10.1007/s00109-011-0837-0
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发表时间：
2012-05-01
影响因子：
4.7
通讯作者：
Fraga, M. F.
中科院分区：
文献类型：
--
作者：
Rodriguez, R. M.;Huidobro, C.;Fraga, M. F.
溴结构域蛋白BRD4参与细胞增殖和细胞周期进程，主要通过其在靶基因的乙酰化染色质依赖的转录调控中发挥作用。在这里，我们发现BRD4在人类结肠癌细胞系和原发肿瘤中经常被异常的启动子高甲基化下调。BRD4在这些结肠癌细胞系中的异位再表达显著降低了体内肿瘤的生长，提示BRD4在人类结肠癌中发挥了作用。
The bromodomain protein BRD4 is involved in cell proliferation and cell cycle progression, primarily through its role in acetylated chromatin-dependent regulation of transcription at targeted loci. Here, we show that BRD4 is frequently downregulated by aberrant promoter hypermethylation in human colon cancer cell lines and primary tumors. Ectopic re-expression of BRD4 in these colon cancer cell lines markedly reduced in vivo tumor growth, suggesting a role of BRD4 in human colon cancer.