Liver damage due to antihypertensive drugs.
Liver damage due to antihypertensive drugs.
复制标题
抗高血压药物引起的肝损伤。
DOI：
10.1111/j.0954-6820.1979.tb00775.x
复制
发表时间：
2009
期刊：
影响因子：
--
通讯作者：
R. Olsson
中科院分区：
文献类型：
--
作者：
R. Olsson
利尿剂、肼屈嗪 首先从四种例外情况开始，有一份关于 c/i/oro/hiuiit/e 胆汁淤积反应的报告（Drerup 等人，1958 年），一份关于胆汁淤积反应的报告（MSD 1964 年），一份关于 eihaayric ad 的肝细胞反应的报告（Datey 等人，1967 年），还有一份报告称肉芽肿性肝炎伴有对/iy（/ru/-mine）的关节发热反应（Jori & Peschle 1973）。仅在第三个病例中进行了激发试验，但在其他病例中，药物与肝脏反应之间的联系似乎相当令人信服。所有这些反应在停药后都是可逆的。它们是在正常剂量的短期用药后出现的，因此似乎是超敏反应。α-甲基LDOPA肝损伤发生率 Gillespie 在 1960 年首次记录了肝细胞功能障碍与服用 α-甲基多巴的关系。在最初的 1,500 名接受该药物的患者中，仅发生了 1 1 例肝功能障碍，发生率低于 1%（Weil 等人，1963 年）。 19691，描述了 823 名患者的发病率为 6.3%，但是，由于在这些系列中没有定期进行激发试验，因此许多记录的肝脏反应可能不是由 α-甲基多巴引起的，有时报告称继续服用该药物后会发生缓解（Leonard）。
DIURETICS, HYDRALAZINE To start with the four exceptions, there is one report of a cholestatic reaction to c/i/oro/hiuiit/e (Drerup et al. 1958), one of a cholestatic (MSD 1964) and one of a hepatocellular reaction to eihaayric ad (Datey et al. 1967) and one of a granulomatous hepatitis concomitant with an arthropatic febrile reaction to/iy (/ru/-mine (Jori & Peschle 1973). Provocation test was performed only in the third case, but also in the other cases the connexion between the drug and the liver reaction appears rather convincing. All these reactions have been reversible after discontinuance of the medication. They have appeared after a short period of medication with ordinary doses and thus appear to have been hypersensitivity reactions.ALPHA-METHY LDOPA LIVER INJURY INCIDENCE The association of hepatocellular dysfunction with administration of alpha-methyldopa was first recorded by Gillespie in 1960. Among the first 1,500 recipients of the drug, only 1 1 instances of hepatic dysfunction occurred, an incidence of less than I%(Weil et al. 1963). On the other hand, in a survey of studies published up to 1969 (Elkington et al. 19691, an incidence of 6.3% of 823 patients was described. However, the incidence varied enormously (from 0 to 35%) between different investigations. Since provocation tests were not regularly performed in these series, many of the recorded hepatic reactions may not have been induced by alpha-methyldopa. In support of this assumption, resolution was sometimes reported to take place when administration of the drug was continued (Leonard