A retrospective study of schistosomiasis-associated pulmonary hypertension from an endemic area in Brazil.
A retrospective study of schistosomiasis-associated pulmonary hypertension from an endemic area in Brazil.
复制标题
巴西血吸虫病流行区与血吸虫病相关的肺动脉高压的回顾性研究。
DOI：
10.1016/j.ijcha.2019.100387
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发表时间：
2019
期刊：
影响因子：
--
通讯作者：
Graham,BrianB
中科院分区：
文献类型：
--
作者：
Botoni,FernandoAntônio;Marinho,CarolinaCoimbra;Carvalho,ViniciusTostes;Mickael,ClaudiaS;Graham,BrianB
DOI of original article: https://doi. org/10.1016/j. ijcha. 2019.1003 3. 7 could not assess if the patients had ongoing Schistosoma infection, if they were only exposed earlier in life, if they were reinfected during follow up, or if they received anti-helmenthic therapy: considering patients in this series live in an endemic area, there is a substantial risk patients could be re-infected and require additional anti-helminthic treatment.We suggest the ideal next step in studying Sch-PAH would be a prospective observation cohort study, ideally done across multiple centers such as those in both endemic and non-endemic regions, inclusive of both incident and prevalent cases. As suggested by the data here, there are likely differences in presentation and outcome between endemic and non-endemic regions. Appropriate control groups would include subjects with hepatosplenic disease without PAH, and other forms of PAH. Prospective collection and analysis of biomarkers would allow identification of potential mechanisms that contribute to the pathophysiology of PAH due to schistosomiasis infection, and factors that impact clinical outcome. In this manner, targeted therapies for Sch-PAH can be developed, beyond vasodilator therapy which is the current mainstay of treatment. Future treatments may also extend to other forms of inflammatory PAH, including that due to HIV infection or autoimmune diseases.
