Participation bias in a randomised trial of screening for lung cancer
Participation bias in a randomised trial of screening for lung cancer
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DOI：
10.1016/j.lungcan.2010.12.018
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发表时间：
2011-09-01
期刊：
影响因子：
5.3
通讯作者：
Brodersen, John
中科院分区：
文献类型：
--
作者：
Hestbech, Mie Sara;Siersma, Volkert;Brodersen, John
简介：参与偏倚可能会影响随机对照试验的结果和代表性。我们调查了丹麦肺癌筛查试验 (DLCST) 中社会人口统计学和社会心理参与偏差的程度。方法：在 DLCST 中，使用问卷 COS-LC（肺癌筛查的后果）来衡量筛查的社会心理方面。为了调查与丹麦人口中具有可比代表性样本的差异，我们向从中央国民登记册中随机抽取的 3999 名 50 至 70 岁的丹麦人发出了纳入调查问卷。完成纳入调查问卷并符合 DLCST 纳入标准的人员将获得 COS-LC。那些完成 COS-LC 并由此形成与 DLCST 相当的人口样本的人，与 DLCST 参与者在社会人口统计学和心理社会测量方面进行了比较。 结果：可比人口样本中的参与率很高：75.3% 完成了纳入调查问卷，77.4% 的合格人员完成了 COS-LC。分析揭示了 DLCST 参与者与可比人口样本在以下社会人口统计学方面的差异：社会群体、独居、性别、年龄和地理区域。 DLCST 参与者报告的负面心理社会方面比可比较的人口样本要少。结论：本研究表明 DLCST 存在显着的社会人口和社会心理参与偏差。 (C) 2011 Elsevier Ireland Ltd. 保留所有权利。
Introduction: Participation bias might affect the results and the representability of randomised controlled trials. We investigated the degree of socio-demographic and psychosocial participation bias in the Danish Lung Cancer Screening Trial (DLCST).Methods: In DLCST the questionnaire COS-LC (Consequences of Screening in Lung Cancer) was used to measure the psychosocial aspects of screening. To investigate a difference with a comparable representative sample from the Danish population, we sent out an inclusion questionnaire to 3999 Danes in the age from 50 to 70 years randomly selected from the Central National Register. Those who completed the inclusion questionnaire and met the inclusion criteria from DLCST received the COS-LC. Those who completed the COS-LC-and thus formed a population sample comparable to DLCST - were compared to the DLCST participants on socio-demographics and psychosocial measures.Results: Participation rates were high among the comparable population sample: 75.3% completed the inclusion questionnaire and 77.4% of those who were eligible completed the COS-LC. The analyses revealed differences between the DLCST participants and the comparable population sample in the following socio-demographic aspects: social group, living alone, gender, age and geographical area. DLCST participants reported less negative psychosocial aspects than the comparable population sample.Conclusion: The present study has shown substantial socio-demographic and psychosocial participation bias in DLCST. (C) 2011 Elsevier Ireland Ltd. All rights reserved.