Relationship between levels of indinavir in hair and virologic response to highly active antiretroviral therapy
Relationship between levels of indinavir in hair and virologic response to highly active antiretroviral therapy
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DOI：
10.7326/0003-4819-137-8-200210150-00009
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发表时间：
2002-10-15
影响因子：
39.2
通讯作者：
Perronne, C
中科院分区：
文献类型：
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作者：
Bernard, L;Vuagnat, A;Perronne, C
背景资料：在接受高效抗逆转录病毒疗法（HAART）治疗的HIV感染患者中，抗逆转录病毒药物的次优水平导致病毒学失败。目的：评估头发中茚地那韦水平与病毒学结果之间的关系。设计：横断面研究。设置：法国的7家AIDS诊所。患者：89名接受包括茚地那韦的HAART治疗的HIV感染患者。测量：根据采集毛发时的病毒血症，将患者分为应答者或无应答者。结果：65名应答者的平均茚地那韦水平（+/-SD）显著高于24名无应答者（24.4 +/- 16 μ g/g对12.9 +/- 8.6 μ g/g）（P < 0.001）。中等水平的茚地那韦在头发中的无应答者有更多的蛋白酶基因的突变，比无应答者低水平的茚地那韦在hair.Conclusion：茚地那韦水平在头发中与接受HAART的患者的病毒学结果。
Background: Suboptimal levels of antiretroviral drugs result in virologic failure in HIV-infected patients treated with highly active antiretroviral therapy (HAART).Objective: To assess the relationship between levels of indinavir in hair and virologic outcome.Design: Cross-sectional study.Setting: 7 AIDS clinics in France.Patients: 89 HIV-infected patients who received HAART that included indinavir.Measurements: Patients were classified as responders or nonresponders on the basis of viremia at the time of hair collection. in nonresponders, levels of indinavir in hair and resistance mutations in the protease gene were assessed at baseline and at the time of indinavir measurement.Results: Mean indinavir levels (+/-SD) were significantly higher in the 65 responders than in the 24 nonresponders (24.4 +/- 16 mug/g vs. 12.9 +/- 8.6 mug/g) (P < 0.001). Nonresponders with intermediate levels of indinavir in hair had more mutations in the protease gene than did nonresponders with low levels of indinavir in hair.Conclusion: Indinavir levels in hair are associated with virologic outcome in patients receiving HAART.