Pre-treatment neutrophil to lymphocyte ratio predicts the chemoradiotherapy outcome and survival in patients with oral squamous cell carcinoma: a retrospective study.
Pre-treatment neutrophil to lymphocyte ratio predicts the chemoradiotherapy outcome and survival in patients with oral squamous cell carcinoma: a retrospective study.
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DOI：
10.1186/s12885-016-2079-6
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发表时间：
2016-01-26
期刊：
影响因子：
3.8
通讯作者：
Nakayama H
中科院分区：
文献类型：
--
作者：
Nakashima H;Matsuoka Y;Yoshida R;Nagata M;Hirosue A;Kawahara K;Sakata J;Arita H;Hiraki A;Nakayama H
中性粒细胞/淋巴细胞比率(NLR)在多种癌症患者中具有预后价值。然而，其在口腔鳞状细胞癌(OSCC)患者中的预后意义还没有得到充分的探讨。本研究的目的是确定口腔鳞癌患者NLR的临床意义。以5-氟尿嘧啶(5-FU)为基础的放化疗后接受手术的口腔鳞癌患者纳入本研究。研究NLR状态与各种临床病理特征之间的关系，并评估NLR对预后的影响。检测外周血中白介素6(IL-6)水平，并与NLR、C反应蛋白浓度(CRP)进行相关性分析。NLR升高与T分期晚期和放化疗反应差显著相关。此外，基于无病生存率的COX回归分析显示，口腔鳞癌患者的非肿瘤转移状态(风险比，2.013；P = 0.041)和放化疗的病理反应(风险比，0.226；P = 0.001)是影响口腔鳞癌患者预后的重要因素。此外，还发现循环IL-6与NLR和CRP相关。NLR是预测5-FU为主的放化疗的临床疗效和患者生存的潜在生物标志物，全身炎症反应可能是改善患者预后的潜在靶点。本文的在线版本(doi：10.1186/s12885-0162079-6)包含补充材料，授权用户可以使用。
The Neutrophil to lymphocyte ratio (NLR) has prognostic value in patients with a variety of cancers. However, its prognostic significance in oral squamous cell carcinoma (OSCC) patients has not been fully explored. The purpose of this study was to determine the clinical significance of NLR in patients with OSCC. OSCC patients who underwent surgery following 5-fluorouracil (5-FU)-based chemoradiotherapy were enrolled in this study. The associations between the NLR status and various clinicopathological features were examined, and the effects of the NLR on the prognosis were evaluated. Analysis of circulating interleukin-6 (IL-6) was carried out and correlation with NLR and C-reactive protein concentration (CRP) was examined. An elevated NLR was significantly correlated with advanced T-stage and poor response to chemoradiotherapy. Moreover, a Cox regression analysis based on the disease-free survival (DFS) revealed the NLR status (hazard ratio, 2.013; P = 0.041) and pathological response to chemoradiotherapy (hazard ratio, 0.226; P = 0.001) to be significant prognostic factors in OSCC patients. Furthermore, circulating IL-6 was found to correlate with NLR and CRP. The NLR is a potential biomarker for predicting the clinical response to 5-FU-based chemoradiotherapy and the survival in OSCC patients, and the systemic inflammatory response may be potential target for improving patient’s prognosis. The online version of this article (doi:10.1186/s12885-016-2079-6) contains supplementary material, which is available to authorized users.