A cross-sectional serum investigation of a clustering hepatitis C virus infection in Southwest China
A cross-sectional serum investigation of a clustering hepatitis C virus infection in Southwest China
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DOI：
10.1002/jmv.25315
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发表时间：
2019-03-01
影响因子：
12.7
通讯作者：
Zhao，Ping
中科院分区：
文献类型：
--
作者：
Peng，Haoran;Zhang，Longyan;Zhao，Ping
在一个聚集性丙型肝炎病毒（HCV）感染的村庄收集血清样本。检测HCV抗体、HCV RNA载量、肝功能指标、HCV包膜抗体和中和活性。在851份成人血清中，342份抗HCV阳性。在这些阳性样本中，254例（74.3%）为HCV RNA阳性（≥800拷贝/mL）。69例患儿血清均未检出HCV抗体或RNA阳性。在HCV抗体阳性血清中，丙氨酸氨基转移酶和天冬氨酸氨基转移酶水平随病毒载量的增加而升高，但当病毒载量高于1 × 106拷贝/mL时，丙氨酸氨基转移酶和天冬氨酸氨基转移酶水平下降。HCV包膜抗体和中和抗体水平随着病毒载量的增加而增加。
Serum samples were collected in a village with a clustering hepatitis C virus (HCV) infection. HCV antibody, HCV RNA loads, liver function indexes, HCV envelope antibody, and neutralizing activity were assessed. Among 851 adult sera, 342 samples were positive for anti‐HCV. Of these positive samples, 254 (74.3%) were HCV RNA positive (≥800 copies/mL). None of the 69 children's sera were positive for HCV antibody or RNA. Among the HCV antibody positive sera, alanine aminotransferase, and aspartate aminotransferase levels increased with the higher virus loads, but decreased when virus loads were higher than 1 × 10 6 copies/mL. HCV envelope antibody and neutralizing antibody levels increased with viral load.