Cardiolipin-mediated cellular signaling.
Cardiolipin-mediated cellular signaling.
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DOI：
10.1007/978-94-007-6331-9_11
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发表时间：
2013
影响因子：
--
通讯作者：
Vinay A Patil;M. Greenberg
中科院分区：
文献类型：
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作者：
Vinay A Patil;M. Greenberg
This review focuses on recent studies showing that cardiolipin (CL), a unique mitochondrial phospholipid, regulates many cellular functions and signaling pathways, both inside and outside the mitochondria. Inside the mitochondria, CL is a critical target of mitochondrial generated reactive oxygen species (ROS) and regulates signaling events related to apoptosis and aging. CL deficiency causes perturbation of signaling pathways outside the mitochondria, including the PKC-Slt2 cell integrity pathway and the high osmolarity glycerol (HOG) pathway, and is a key player in the cross-talk between the mitochondria and the vacuole. Understanding these connections may shed light on the pathology of Barth syndrome, a disorder of CL remodeling.
