A Gastroenterologist's Guide to Probiotics
A Gastroenterologist's Guide to Probiotics
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DOI：
10.1016/j.cgh.2012.03.024
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发表时间：
2012-09-01
影响因子：
12.6
通讯作者：
Ciorba, Matthew A.
中科院分区：
文献类型：
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作者：
Ciorba, Matthew A.
肠道微生物群有助于胃肠道健康，它们的破坏与许多疾病状态有关。一些患者食用益生菌产品是为了控制肠道菌群以获得健康益处。对于胃肠病学家来说，提高他们对益生菌作用机制的理解以及在实践中支持其使用的证据是很重要的。临床试验已经评估了益生菌制剂对几种疾病的治疗效果，包括与抗生素或艰难梭菌相关的腹泻、肠易激综合征和炎症性肠病。虽然益生菌研究是一个快速发展的领域，但有足够的数据证明益生菌用于治疗或预防这些疾病的试验是合理的。然而，益生菌改善疾病症状的能力可能是适度的，并且在不同的益生菌菌株之间有所不同——并不是所有的益生菌都适用于所有的疾病。目前的综述提供了使用益生菌治疗的特定条件的基本原理和基于文献的建议。
The enteric microbiota contribute to gastrointestinal health, and their disruption has been associated with many disease states. Some patients consume probiotic products in attempts to manipulate the intestinal microbiota for health benefit. It is important for gastroenterologists to improve their understanding of the mechanisms of probiotics and the evidence that support their use in practice. Clinical trials have assessed the therapeutic effects of probiotic agents for several disorders, including antibiotic-or Clostridium difficile-associated diarrhea, irritable bowel syndrome, and the inflammatory bowel diseases. Although probiotic research is a rapidly evolving field, there are sufficient data to justify a trial of probiotics for treatment or prevention of some of these conditions. However, the capacity of probiotics to modify disease symptoms is likely to be modest and varies among probiotic strains-not all probiotics are right for all diseases. The current review provides condition-specific rationale for using probiotic therapy and literature-based recommendations.