Serum concentrations of human hepatocyte growth factor is a useful indicator for predicting the occurrence of hepatocellular carcinomas in C-viral chronic liver diseases
Serum concentrations of human hepatocyte growth factor is a useful indicator for predicting the occurrence of hepatocellular carcinomas in C-viral chronic liver diseases
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DOI：
10.1002/cncr.10732
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发表时间：
2002-08-15
期刊：
影响因子：
6.2
通讯作者：
Arakawa, Y
中科院分区：
文献类型：
--
作者：
Yamagamim, H;Moriyama, M;Arakawa, Y
背景肝细胞生长因子（hepatocyte growth factor，HGF）与肝细胞癌（hepatocellular carcinoma，HCC）发生的关系已被大量报道。在这项研究中，我们检测了血液样本中的血清HGF浓度，并进行了前瞻性研究，以检查慢性丙型病毒性肝炎（CH）和肝硬化患者的长期结局。在这项研究中检查的受试者包括99例C-病毒CH，肝硬化和HCC患者。血清肝细胞生长因子水平测定在48小时内收集的血液样本使用酶联免疫吸附测定试剂盒。肝细胞癌患者血清HGF浓度明显高于肝硬化和肝硬化患者。血小板计数低的患者血清HGF的检出率和平均水平均显著高于血小板计数高的患者。所有血清HGF浓度超过0.6 ng/mL的患者均患有HCC，而与甲胎蛋白水平、维生素K缺乏或血液中拮抗剂II无关。血清HGF浓度随着肝癌占据面积的增加而增加。肝细胞生长因子浓度高的患者发生肝癌的累积发病率明显高于肝细胞生长因子浓度低的患者。多因素分析显示血清HGF水平升高是HCC发生的重要危险因素。血清HGF水平代表了C-病毒CH和肝硬化患者肝脏中致癌状态的程度。因此，血清HGF浓度的测定可作为HCC的第三种肿瘤标志物，用于HCC的检测和随访治疗。(C)2002年美国癌症协会。
BACKGROUND. Numerous reports have examined the relationship between hepatocyte growth factor (HGF) and either the facilitation or suppression of the occurrence of hepatocellular carcinoma (HCC).METHODS. In this study, we measured serum HGF concentrations of blood samples and conducted prospective studies to examine the long-term Outcome of C-viral chronic hepatitis (CH) and cirrhosis in patients. The subjects examined in this study include 99 patients with C-viral CH, cirrhosis, and HCC. The serum HGF level was measured in blood samples within 48 hours of collection using enzyme-linked immunosorbent assay kits.RESULTS. The serum concentrations of HGF were significantly higher in patients with HCC than in patients with CH or cirrhosis. The detection rate of HGF and its mean serum level were significantly higher in patients with a low platelet count than in patients with a high platelet count. All of the patients with serum HGF concentrations of more than 0.6 ng/mL had HCC, irrespective of the levels of a-fetoprotein, vitamin K absence, or antagonist-II in the blood. Serum HGF concentrations increased concomitantly with increases in areas occupied by HCC. The cumulative incidence of occurrence of HCC was significantly higher in patients with high HGF concentrations than in patients with low HGF concentrations. Multivariate analysis revealed that the elevation in serum HGF level is the most important risk factor for the occurrence of HCC.CONCLUSIONS. The serum level of HGF represents the degree of the carcinogenic state in the liver of patients with C-viral CH and cirrhosis. Therefore, the determination of serum HGF concentrations may be useful as a third tumor marker of HCC in detection as well as follow-up therapy. (C) 2002 American Cancer Society.