Caveolae, caveolin and caveolin-rich membrane domains: A signalling hypothesis
Caveolae, caveolin and caveolin-rich membrane domains: A signalling hypothesis
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DOI：
10.1016/0962-8924(94)90114-7
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发表时间：
1994-01-01
影响因子：
19
通讯作者：
Sargiacomo, Massimo
中科院分区：
文献类型：
--
作者：
Lisanti, Michael P.;Scherer, Philipp E.;Sargiacomo, Massimo
小窝，50-100 nm的内陷，代表质膜的一个亚室，已经知道了很多年，但它们的确切作用仍然不确定。研究结果表明，小窝外壳蛋白小窝蛋白是一个V-Src底物和G-蛋白偶联受体存在于小窝，小窝蛋白和跨膜信号之间的关系。最近分离的小窝蛋白丰富的膜结构域，其中小窝蛋白存在作为一个异源寡聚复合物与完整的膜蛋白和已知的细胞质信号分子提供了支持这一假设。小窝内某些信号分子的区室化可以使激活的受体与一个以上的效应系统有效和快速地偶联。
Caveolae, 50–100 nm invaginations that represent a subcompartment of the plasma membrane, have been known for many years, but their exact roles remain uncertain. The findings that the caveola coat protein caveolin is a v-Src substrate and that G-protein-coupled receptors are present in caveolae have suggested a relationship between caveolae, caveolin and transmembrane signalling. The recent isolation of caveolin-rich membrane domains in which caveolin exists as a hetero-oligomeric complex with integral membrane proteins and known cytoplasmic signalling molecules provides support for this hypothesis. Compartmentalization of certain signalling molecules within caveolae could allow efficient and rapid coupling of activated receptors to more than one effector system.