Trigocherrin A, the First Natural Chlorinated Daphnane Diterpene Orthoester from Trigonostemon cherrieri
Trigocherrin A, the First Natural Chlorinated Daphnane Diterpene Orthoester from Trigonostemon cherrieri
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DOI：
10.1021/ol2030907
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发表时间：
2012-01-06
期刊：
影响因子：
5.2
通讯作者：
Litaudon, Marc
中科院分区：
文献类型：
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作者：
Allard, Pierre-Marie;Martin, Marie-Therese;Litaudon, Marc
Trigocherrin A是一种氯化和高度氧化的瑞香烷二萜原酸酯（DDO），从三角蕊木（Trigonostemon cherrieri）的树皮中分离得到。Trigocherrin A是天然存在的卤化DDO的第一个例子。通过核磁共振波谱数据的综合分析确定了其结构，并通过实验和理论计算的ECD谱的比较确定了其绝对构型。Trigocherrin A在Vero细胞中表现出对基孔肯雅病毒的有效和选择性作用。
Trigocherrin A, a chlorinated and highly oxygenated daphnane diterpenold orthoester (DDO), was isolated from the bark of Trigonostemon cherrieri Trigocherrin A is the first example of a naturally occurring halogenated DDO. Its structure was elucidated by comprehensive analysis of NMR spectroscopic data, and its absolute configuration was determined by comparison of experimental and theoretically calculated ECD spectra. Trigocherrin A exhibited a potent and selective effect against Chikungunya virus In Vero cells.