Attenuated anterior cingulate activation during a verbal fluency task in elderly patients with a history of multiple-episode depression.
Attenuated anterior cingulate activation during a verbal fluency task in elderly patients with a history of multiple-episode depression.
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DOI：
10.1097/01.jgp.0b013e31802ea919
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发表时间：
2007-07
期刊：
影响因子：
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通讯作者：
Hiroshi Takami;Y. Okamoto;H. Yamashita;G. Okada;S. Yamawaki
中科院分区：
文献类型：
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作者：
Hiroshi Takami;Y. Okamoto;H. Yamashita;G. Okada;S. Yamawaki
目的以往的研究表明，在老年患者中，既往抑郁在抑郁复发中起作用。本研究旨在探讨老年抑郁症康复者的脑功能及其与抑郁发作次数的关系。方法选择20例老年抑郁症康复期患者和10例健康志愿者。抑郁症患者分为经历过一次抑郁发作和经历过多次抑郁发作的患者。在语言流畅性任务期间，对每个参与者进行功能性磁共振成像。使用统计参数映射分析数据。结果：与其他两组相比，经历过多次抑郁发作的患者前扣带皮层的激活明显减弱。有一个单一的抑郁发作患者和健康志愿者之间的激活区域没有显着差异。结论：这些研究结果表明，前扣带皮层的激活减弱可能与老年人抑郁症的多次发作有关，并与循环或复发的脆弱性有关。
OBJECTIVE Previous studies have suggested that, in elderly patients, prior depression plays a role in the recurrence of depression. The aim of this study was to investigate cerebral brain function in recovered depressed elderly and investigate the relationship between this brain function and the number of depressive episodes. METHODS Twenty elderly depressive patients in recovery and 10 healthy volunteers were included in this study. The depressive patients were divided into those who had experienced a single depressive episode and those who had experienced multiple episodes. Functional magnetic resonance imaging was performed in each participant during a verbal fluency task. The data were analyzed using statistical parametric mapping. RESULTS Activation in the anterior cingulate cortex was significantly attenuated in patients who had experienced multiple depressive episodes, compared with the other two groups. There were no significant differences in areas of activation between patients with a single depressive episode and healthy volunteers. CONCLUSIONS These findings suggest that attenuated activation in the anterior cingulate cortex may be associated with multiple episodes of depression in the elderly and with the vulnerability to cycling or recurrence.